Yangco B G, Eikman E A, Solomon D A, Deresinski S C, Madden J A
Antimicrob Agents Chemother. 1981 Apr;19(4):534-9. doi: 10.1128/AAC.19.4.534.
A rapid radiometric method for susceptibility testing of Mycobacterium avium-intracellulare to eight chemotherapeutic agents was compared with a conventional method. Results were available within 72 h by radiometric testing in contrast to 21 days by the conventional method. The radiometric and conventional methods agreed to 61% of the tests, but growth inhibition of greater than or equal to 50% was detectable only by radiometric testing in an additional 36.5% of the tests. In only 2.5% of the tests was the radiometric method unable to detect complete inhibition shown by the conventional method. Quantifiable increases in inhibition with increasing concentration of isoniazid were more frequently detectable by the radiometric method than by conventional testing. The radiometric method is a simple, rapid, and quantitative test for drug susceptibility of mycobacteria and warrants further investigation.
将一种用于鸟分枝杆菌-胞内分枝杆菌对八种化疗药物敏感性测试的快速放射测量法与传统方法进行了比较。通过放射测量法72小时内可获得结果，而传统方法需要21天。放射测量法和传统方法在61%的测试中结果一致，但在另外36.5%的测试中，仅通过放射测量法才能检测到大于或等于50%的生长抑制。在仅2.5%的测试中，放射测量法无法检测到传统方法显示的完全抑制。与传统测试相比，放射测量法更频繁地检测到随着异烟肼浓度增加抑制作用的可量化增加。放射测量法是一种简单、快速且定量的分枝杆菌药敏测试方法，值得进一步研究。
