Salmeron G, Greenberg S D, Lidsky M D
Arch Intern Med. 1981 Jul;141(8):1005-10.
A retrospective analysis was performed of 105 patients with polymyositis for eight years. Roentgenographic evidence of pulmonary interstitial disease was present in ten adult patients (9%) with polymyositis unassociated with other connective-tissue disorders. Review of the pulmonary histopathologic findings indicated a spectrum of pulmonary diffuse interstitial infiltrates and fibroplasia of the alveolar septae. Response to glucocorticoids with regard to pulmonary symptoms was variable in the patients studied. Therapeutic response seemed to be influenced by both the cellularity of the chronic interstitial infiltrates and the degree of fibroplasia of the alveolar septae. Electron microscopic studies of the lung tissue from two patients with polymyositis and diffuse interstitial lung disease failed to demonstrate either immune complexes or viral particles.
对105例多发性肌炎患者进行了为期八年的回顾性分析。在10例（9%）不伴有其他结缔组织病的成年多发性肌炎患者中，存在肺间质疾病的X线证据。对肺部组织病理学结果的回顾显示，存在一系列肺部弥漫性间质浸润和肺泡间隔的纤维增生。在所研究的患者中，糖皮质激素对肺部症状的反应各不相同。治疗反应似乎受到慢性间质浸润的细胞密度和肺泡间隔纤维增生程度的影响。对两名患有多发性肌炎和弥漫性间质性肺病患者的肺组织进行电子显微镜研究，未发现免疫复合物或病毒颗粒。
