Irwin M, Belendiuk K, McCloskey K, Freedman D X
Am J Psychiatry. 1981 Aug;138(8):1082-5. doi: 10.1176/ajp.138.8.1082.
The authors present the first report, to their knowledge, of hyperserotonemia in children with attentional deficit disorder who had normal intelligence. Hyperserotonemic children had significantly lower levels of plasma total and protein-bound tryptophan and a higher percentage of free tryptophan than those with normal serotonin levels. Plasma kynurenine did not differ, suggesting that the hyperserotonemia is not due to a blockade of the kynurenine pathway but may reflect on increase in tissue tryptophan uptake and use.
据作者所知，本文首次报道了智力正常的注意力缺陷障碍儿童血清素过多症。血清素过多的儿童血浆总色氨酸和蛋白结合色氨酸水平显著低于血清素水平正常的儿童，游离色氨酸百分比则更高。血浆犬尿氨酸无差异，这表明血清素过多症并非由于犬尿氨酸途径受阻，而可能反映出组织色氨酸摄取和利用增加。
