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用于检测人类肿瘤的单克隆抗体：一种实验方法。

Monoclonal antibodies to detect human tumours: an experimental approach.

作者信息

Moshakis V, McIlhinney R, Raghavan D, Neville A M

出版信息

J Clin Pathol. 1981 Mar;34(3):314-9. doi: 10.1136/jcp.34.3.314.

DOI:10.1136/jcp.34.3.314
PMID:6785322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1146483/
Abstract

The use of monoclonal antibodies which can be raised to antigens of choice offers a selective and specific approach for the detection of tumours both in vivo and at a cellular level in biopsy specimens. We demonstrate that a monoclonal antibody raised to human teratoma will localise in a teratoma, growing as a xenograft in immune-suppressed mice.

摘要

能够针对选定抗原产生的单克隆抗体，为在体内和活检标本的细胞水平上检测肿瘤提供了一种选择性和特异性的方法。我们证明，一种针对人畸胎瘤产生的单克隆抗体将定位在作为异种移植瘤生长于免疫抑制小鼠体内的畸胎瘤中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa4/1146483/81a9abcabfaa/jclinpath00475-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa4/1146483/344eefb8d1d1/jclinpath00475-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa4/1146483/979bcc5d16eb/jclinpath00475-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa4/1146483/81a9abcabfaa/jclinpath00475-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa4/1146483/344eefb8d1d1/jclinpath00475-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa4/1146483/979bcc5d16eb/jclinpath00475-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa4/1146483/81a9abcabfaa/jclinpath00475-0090-a.jpg

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Monoclonal antibodies to detect human tumours: an experimental approach.用于检测人类肿瘤的单克隆抗体：一种实验方法。
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2
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本文引用的文献

1
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
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Localisation of tumour deposits by external scanning after injection of radiolabelled anti-carcinoembryonic antigen.注射放射性标记的抗癌胚抗原后通过外部扫描对肿瘤沉积物进行定位。
Br Med J. 1980 Jan 26;280(6209):220-2. doi: 10.1136/bmj.280.6209.220.
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Potential pathological application of immunocytochemical methods to the detection of micrometastases.
使用菁共轭单克隆抗体进行体内肿瘤标记
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Localization of human breast-carcinoma xenografts using antibodies to carcinoembryonic antigen.利用癌胚抗原抗体对人乳腺癌异种移植瘤进行定位
Br J Cancer. 1981 May;43(5):575-81. doi: 10.1038/bjc.1981.86.
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Detection of human cancer in an animal model using radio-labelled tumour-associated monoclonal antibodies.使用放射性标记的肿瘤相关单克隆抗体在动物模型中检测人类癌症。
Br J Cancer. 1982 Jul;46(1):1-8. doi: 10.1038/bjc.1982.157.
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Monoclonal antibodies in oncology.肿瘤学中的单克隆抗体
J Clin Pathol. 1982 Apr;35(4):369-75. doi: 10.1136/jcp.35.4.369.
7
Localization of human tumour xenografts after i.v. administration of radiolabeled monoclonal antibodies.静脉注射放射性标记单克隆抗体后人类肿瘤异种移植的定位
Br J Cancer. 1981 Jul;44(1):91-9. doi: 10.1038/bjc.1981.153.
8
Scanning for tumours with radiolabelled antibodies: a review.用放射性标记抗体扫描肿瘤：综述
J R Soc Med. 1983 Nov;76(11):957-60. doi: 10.1177/014107688307601113.
9
Antitumor monoclonal antibodies for radioimmunodetection of tumors and drug targeting.用于肿瘤放射免疫检测和药物靶向的抗肿瘤单克隆抗体。
Cancer Metastasis Rev. 1983;2(1):89-106. doi: 10.1007/BF00046907.
10
Localisation of metastatic carcinoma by a radiolabelled monoclonal antibody.用放射性标记单克隆抗体对转移性癌进行定位
Br J Cancer. 1983 Feb;47(2):253-9. doi: 10.1038/bjc.1983.33.
免疫细胞化学方法在微转移检测中的潜在病理学应用。
Cancer Res. 1980 Aug;40(8 Pt 2):3079-82.
4
Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen.用癌胚抗原放射性抗体进行癌症的放射免疫检测。
Cancer Res. 1980 Aug;40(8 Pt 2):2984-92.
5
Assessment of biochemical tests to screen for metastases in patients with breast cancer.评估用于筛查乳腺癌患者转移情况的生化检测
Lancet. 1980 Feb 9;1(8163):296-7. doi: 10.1016/s0140-6736(80)90790-4.
6
Continuous cultures of fused cells secreting antibody of predefined specificity.分泌预定义特异性抗体的融合细胞的连续培养物。
Nature. 1975 Aug 7;256(5517):495-7. doi: 10.1038/256495a0.
7
Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy.通过放射性标记的单克隆抗体和外部闪烁扫描法检测肿瘤位置。
Science. 1979 Nov 16;206(4420):844-7. doi: 10.1126/science.493985.
8
Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning.
N Engl J Med. 1978 Jun 22;298(25):1384-6. doi: 10.1056/NEJM197806222982503.