Fidler I J, Hart I R
Cancer Res. 1981 Aug;41(8):3266-7.
The K-1735 melanoma is a transplantable murine tumor which, when growing s.c., is composed of melanotic and amelanotic areas. Results from trocar transplantation studies of tumor fragments show that expression of this phenotypic diversity can be terminated within very few passages. In parallel experiments, passage of cell suspensions derived from the whole tumor maintains this heterogeneity of melanin production. The implications of these findings are discussed.
K-1735黑色素瘤是一种可移植的鼠类肿瘤，当它在皮下生长时，由黑色素沉着区和无黑色素沉着区组成。肿瘤碎片的套管针移植研究结果表明，这种表型多样性的表达在很少的传代次数内就可以终止。在平行实验中，来自整个肿瘤的细胞悬液传代能维持这种黑色素生成的异质性。本文讨论了这些发现的意义。
