南非多乳鼠中抗乙酰胆碱受体抗体的缺失。
Absence of anti-acetylcholine receptor antibodies in Praomys (Mastomys) natalensis.
作者信息
Vincent A, Solleveld H A
出版信息
Clin Exp Immunol. 1981 Jan;43(1):94-8.
It has been suggested in the past that Praomys (Mastomys) natalensis might be an animal model for human myasthenia gravis. This suggestion was based on the occurrence of thymomas and autoantibody to striated muscle in this animal species. Myasthenia gravis in man is associated with anti-striated muscle antibody and thymoma as well as antiacetylcholine receptor antibody. This prompted us to search for such autoantibodies in Mastomys. There was no evidence of anti-acetylcholine receptor antibody in any of the serum samples tested. The titres found in Mastomys correspond to those observed in human control sera. No difference was found in the number of alpha-bungarotoxin-binding sites at the motor endplate and in muscle extracts between animals with and without thymoma and with and without anti-striated muscle antibody. These findings lead to the conclusion that it is very unlikely that myasthenia gravis occurs with any frequency in Praomys (Mastomys) natalensis.
过去有人提出，南非多乳鼠可能是人类重症肌无力的动物模型。这一建议基于该动物物种中胸腺瘤和抗横纹肌自身抗体的出现。人类重症肌无力与抗横纹肌抗体、胸腺瘤以及抗乙酰胆碱受体抗体有关。这促使我们在南非多乳鼠中寻找此类自身抗体。在所检测的任何血清样本中均未发现抗乙酰胆碱受体抗体的证据。在南非多乳鼠中发现的滴度与在人类对照血清中观察到的滴度相当。在有或无胸腺瘤以及有或无抗横纹肌抗体的动物之间，运动终板和肌肉提取物中α-银环蛇毒素结合位点的数量没有差异。这些发现得出结论，南非多乳鼠中发生重症肌无力的频率极不可能。
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