Peters L L, Hoefer M T, Ben-Jonathan N
Science. 1981 Aug 7;213(4508):659-61. doi: 10.1126/science.7256264.
Removal of the posterior pituitary from anesthetized male rats results in a prompt and significant increase in circulating prolactin that is reversed by the injection of dopamine. Posterior pituitary extracts, which contain high concentrations of endogenous dopamine, inhibit prolactin secretion from isolated anterior pituitary cells. This inhibition is prevented by incubation of the cells with the dopamine receptor antagonist (+)-butaclamol. The data show that posterior pituitary dopamine reaches the anterior pituitary via the short hypophysial portal vessels and participates in the regulation of prolactin secretion.
切除麻醉的雄性大鼠的垂体后叶会导致循环催乳素迅速且显著增加，而注射多巴胺可使其逆转。垂体后叶提取物含有高浓度的内源性多巴胺，可抑制分离的垂体前叶细胞分泌催乳素。多巴胺受体拮抗剂（+）-布他拉莫与细胞共同孵育可阻止这种抑制作用。数据表明，垂体后叶多巴胺通过短垂体门脉血管到达垂体前叶，并参与催乳素分泌的调节。
