Mogadam M, Korelitz B I, Ahmed S W, Dobbins W O, Baiocco P J
Am J Gastroenterol. 1981 Apr;75(4):265-9.
To determine whether pregnancy influences the course of inflammatory bowel disease, a survey of 324 patients, 178 with ulcerative colitis and 146 with Crohn's disease was carried out. During pregnancy, 70% of the patients remained unchanged or improved, whereas 30% developed exacerbations. The course of the disease was significantly milder in patients who became pregnant while in remission, as compared to those with moderate to severe disease (P less than 0.001). Postpartum, only 13% of patients, with quiescent to mild disease at term, experienced moderate to severe disease in contrast to 53% of those with active disease (P less than 0.001). We conclude that: 1. The course of inflammatory bowel disease is not adversely affected by concurrent pregnancy or postpartum 2. Exacerbations during or after pregnancy are more frequent in patients with active or uncontrolled disease. 3. Since the risk of relapse during pregnancy and postpartum is significantly lower in patients with inactive disease, treatment designed to induce and maintain remission in the course of pregnancy should minimize such exacerbations.
为了确定妊娠是否会影响炎症性肠病的病程，我们对324例患者进行了调查，其中178例患有溃疡性结肠炎，146例患有克罗恩病。在孕期，70%的患者病情保持稳定或好转，而30%的患者病情加重。与中度至重度疾病患者相比，处于缓解期时怀孕的患者疾病进程明显较轻（P<0.001）。产后，足月时病情静止至轻度的患者中只有13%经历了中度至重度疾病，而活动性疾病患者中这一比例为53%（P<0.001）。我们得出以下结论：1. 炎症性肠病的病程不会受到同时存在的妊娠或产后情况的不利影响。2. 患有活动性或未控制疾病的患者在孕期或产后病情加重更为频繁。3. 由于无活动性疾病的患者在孕期和产后复发风险显著较低，旨在诱导和维持孕期病情缓解的治疗应尽量减少此类病情加重。
