[Hepatocyte ultrastructure during accumulation and secretion of bile products].

It has been established that the time course of alterations in the ultrastructure of chick embryo hepatocytes in the course of synthesis, accumulation and secretion of bile products involves 1) an increase in the hepatocytic cytoplasm of the number of small profiles of smooth endoplasmic reticulum with the particles resembling very low electronic density lipids; 2) an abrupt increase in the size of Golgi complex; accumulation of material of different electron density in the enlarged areas of Golgi cisterns; 3) bubbling out of small vesicles and large vacuoles containing material of different electron density from Golgi complex; localization of small vesicles, large vacuoles and mitochondria with translucent matrix about the bile canaliculus; 4) localization of Golgi complex somewhat farther from the bile canaliculus than before; 5) fusing of the membranes of the small vesicles with the bile canalicular membrane thereby producing secretion of bile products an; d clasmatosis of mitochondrial fragments; 6) enlargement of the bile canalicular lumen, accumulation of material of different electron density in the canaliculus.