Flood J F, Landry D W, Jarvik M E
Brain Res. 1981 Jun 29;215(1-2):177-85. doi: 10.1016/0006-8993(81)90500-x.
Mice were treated on active avoidance to determine the effect of cholinergic and anticholinergic drugs on retention. All drugs were administered intraventricularly after training and one week prior to testing retention. A dose-response curve was determined for each drug. The results indicate that each of 6 anticholinergics impaired retention. The 8 cholinergic drugs tested all yielded U-shaped dose-response curves with controls showing poor retention, low doses of the drugs yielding good retention and high doses resulting in poor retention.
对小鼠进行主动回避实验，以确定胆碱能和抗胆碱能药物对记忆保持的影响。所有药物均在训练后及测试记忆保持前一周通过脑室内注射给药。测定了每种药物的剂量-反应曲线。结果表明，6种抗胆碱能药物中的每一种都损害了记忆保持。所测试的8种胆碱能药物均产生了U形剂量-反应曲线，对照组的记忆保持较差，低剂量药物可产生良好的记忆保持，而高剂量则导致记忆保持较差。
