伴有2/8易位的伯基特淋巴瘤：一份特别提及临床特征的病例报告

Burkitt's lymphoma with 2/8 translocation: a case report with special reference to the clinical features.

作者信息

Abe R, Hayashi Y, Sampi K, Sakurai M

出版信息

Cancer Genet Cytogenet. 1982 Jun;6(2):135-52. doi: 10.1016/0165-4608(82)90078-4.

Abstract

A case of Japanese Burkitt's lymphoma (BL) with a t(2; 8) (p11; q24), a variant translocation in BL, is reported. The patient was a 45-year-old woman in whom a subcutaneous right axillary tumor first occurred. Remission was not achieved despite extensive chemotherapy. Of the four nonendemic BL, two endemic BL, and one nonendemic Burkitt-type acute lymphocytic leukemia (ALL-L3) cases with a t(2; 8) reported so far, including the present case, four (two nonendemic and two endemic) were positive for Epstein-Barr virus-determined nuclear antigen (EBNA) and two revealed extremely high antibody titers against Epstein-Barr virus (EBV), the remaining one not having been tested for EBV. Thus, a possible close relationship between the t(2; 8) and EBV infection has to be considered. The t(2; 8) in nonendemic BL seems to occur more often in adults than in children.

摘要

报告了一例患有t(2; 8)(p11; q24)的日本伯基特淋巴瘤（BL）病例，这是BL中的一种变异易位。患者为一名45岁女性，最初在右腋窝出现皮下肿瘤。尽管进行了广泛化疗，但未实现缓解。在迄今为止报告的包括本病例在内的4例非地方性BL、2例地方性BL和1例患有t(2; 8)的非地方性伯基特型急性淋巴细胞白血病（ALL-L3）病例中，4例（2例非地方性和2例地方性）的爱泼斯坦-巴尔病毒核抗原（EBNA）呈阳性，2例显示出针对爱泼斯坦-巴尔病毒（EBV）的极高抗体滴度，其余1例未检测EBV。因此，必须考虑t(2; 8)与EBV感染之间可能存在的密切关系。非地方性BL中的t(2; 8)似乎在成人中比在儿童中更常见。