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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Clamp J R, Fraser G, Read A E

Clin Sci (Lond). 1981 Aug;61(2):229-34. doi: 10.1042/cs0610229.

Mucus samples obtained from colectomy colons from 10 patients with ulcerative colitis and four patients with Crohn's disease of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated from mucosal scrapings by gel-permeation chromatography. The high-molecular-weight fraction consisted largely of mucus glycoproteins and was further purified to the glycopolypeptides. The low-molecular-weight fraction contained a glycoprotein with a high mannose content. The carbohydrate content of both the mucus glycoprotein and glycopolypeptide fractions were significantly reduced in active colitis. 3. Oligosaccharides were prepared from the mucus glycoprotein material. In the normal material more than half the units contained eight or more monosaccharide residues, whereas in the disease material the bulk of the units were smaller than this.

我们研究了从10例溃疡性结肠炎患者和4例结肠克罗恩病患者的结肠切除标本中获取的黏液样本，以及10例正常尸检结肠的样本。2. 通过凝胶渗透色谱法从黏膜刮片中分离出两个糖蛋白组分。高分子量组分主要由黏液糖蛋白组成，并进一步纯化至糖多肽。低分子量组分含有一种高甘露糖含量的糖蛋白。在活动性结肠炎中，黏液糖蛋白和糖多肽组分的碳水化合物含量均显著降低。3. 从黏液糖蛋白材料中制备了寡糖。在正常材料中，超过一半的单元含有八个或更多的单糖残基，而在病变材料中，大部分单元小于此数。

Clamp J R, Fraser G, Read A E

Clin Sci (Lond). 1981 Aug;61(2):229-34. doi: 10.1042/cs0610229.

Mucus samples obtained from colectomy colons from 10 patients with ulcerative colitis and four patients with Crohn's disease of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated from mucosal scrapings by gel-permeation chromatography. The high-molecular-weight fraction consisted largely of mucus glycoproteins and was further purified to the glycopolypeptides. The low-molecular-weight fraction contained a glycoprotein with a high mannose content. The carbohydrate content of both the mucus glycoprotein and glycopolypeptide fractions were significantly reduced in active colitis. 3. Oligosaccharides were prepared from the mucus glycoprotein material. In the normal material more than half the units contained eight or more monosaccharide residues, whereas in the disease material the bulk of the units were smaller than this.

我们研究了从10例溃疡性结肠炎患者和4例结肠克罗恩病患者的结肠切除标本中获取的黏液样本，以及10例正常尸检结肠的样本。2. 通过凝胶渗透色谱法从黏膜刮片中分离出两个糖蛋白组分。高分子量组分主要由黏液糖蛋白组成，并进一步纯化至糖多肽。低分子量组分含有一种高甘露糖含量的糖蛋白。在活动性结肠炎中，黏液糖蛋白和糖多肽组分的碳水化合物含量均显著降低。3. 从黏液糖蛋白材料中制备了寡糖。在正常材料中，超过一半的单元含有八个或更多的单糖残基，而在病变材料中，大部分单元小于此数。