Barney C C, Elizondo R S
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun;50(6):1248-54. doi: 10.1152/jappl.1981.50.6.1248.
The role of prostaglandins in nonfebrile temperature regulation in the rhesus monkey (Macaca mulatta) was investigated, Indomethacin, a potent inhibitor of prostaglandin synthesis, produced only a slight (less than 0.8 degrees C) fall in core temperature when administered intravenously (2-4 mg/kg) to warm-, cold-, and nonacclimated afebrile rhesus monkeys at ambient temperatures of 18, 27, and 33 degrees C. The fall in the core temperature was independent of the state of temperature acclimation and was brought about by nonregulated means. In addition, cold acclimation in the rhesus monkey was not associated with any change in hypothalamic sensitivity to the hyperthermic effects of exogenous prostaglandin E1. The results indicate that hypothalamic prostaglandins are not involved in normal temperature regulation of the monkey or in the process of temperature acclimation.
研究了前列腺素在恒河猴非发热体温调节中的作用。吲哚美辛是一种有效的前列腺素合成抑制剂，当以静脉注射方式（2 - 4毫克/千克）给予处于18℃、27℃和33℃环境温度下的热适应、冷适应和未适应的无热恒河猴时，仅使核心体温略有下降（低于0.8摄氏度）。核心体温的下降与温度适应状态无关，是通过非调节方式引起的。此外，恒河猴的冷适应与下丘脑对外源性前列腺素E1热效应的敏感性变化无关。结果表明，下丘脑前列腺素不参与猴子的正常体温调节或温度适应过程。
