暴发性乙型肝炎患者血清对培养的离体大鼠肝细胞的肝毒性作用。

Hepatotoxic effects of sera from patients with fulminant hepatitis B on isolated rat hepatocytes in culture.

作者信息

Haas T, Holloway C J, Osterthun V, Trautschold I

出版信息

J Clin Chem Clin Biochem. 1981 May;19(5):283-6. doi: 10.1515/cclm.1981.19.5.283.

DOI:10.1515/cclm.1981.19.5.283

Abstract

The hepatotoxicity of sera from patients with terminal fulminant hepatic failure has been investigated by cell culture techniques. It could be shown that both untreated and heat-treated sera are cytotoxic in nature. Compared with the action of sera from healthy individuals on liver cells in primary monolayer culture, the pathological sera exhibited significantly different behaviour with respect to morphological and biochemical parameters such as cell adhesion, growth and proliferation, and enzyme release.

摘要

采用细胞培养技术研究了晚期暴发性肝衰竭患者血清的肝毒性。结果表明，未经处理和经热处理的血清本质上均具有细胞毒性。与健康个体血清对原代单层培养肝细胞的作用相比，病理血清在细胞黏附、生长和增殖以及酶释放等形态学和生化参数方面表现出显著不同的行为。

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