γ-氨基丁酸拮抗剂与Y型猫视网膜神经节细胞的空间总和
GABA-antagonists and spatial summation in Y-type cat retinal ganglion cells.
作者信息
Kirby A W, Schweitzer-Tong D E
出版信息
J Physiol. 1981 Mar;312:335-44. doi: 10.1113/jphysiol.1981.sp013631.
Abstract
- The effect of GABA-antagonists on centre size of Y-type retinal ganglion cells was measured under conditions which ensured that cells were rod driven. 2. Both bicuculline and picrotoxin, administered intravenously, led to reliable and reversible changes in centre size as determined by area-sensitivity measurements. 3. The administration of GABA-antagonists produced opposite results in on- and off-centre cells; the centre summing area decreased in on-centre cells and increased in off-centre cells.
摘要
- 在确保细胞由视杆细胞驱动的条件下，测量了γ-氨基丁酸（GABA）拮抗剂对Y型视网膜神经节细胞中心大小的影响。2. 通过面积敏感性测量确定，静脉注射荷包牡丹碱和印防己毒素均导致中心大小出现可靠且可逆的变化。3. GABA拮抗剂的给药在中心兴奋型和中心抑制型细胞中产生了相反的结果；中心兴奋型细胞的中心总和面积减小，而中心抑制型细胞的中心总和面积增加。
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