Ferguson M M, Carter J, Boyle P, Hart D M, Lindsay R
J R Soc Med. 1981 Jul;74(7):492-8. doi: 10.1177/014107688107400707.
Numerous oral complaints have been attributed to the female climacteric including altered taste, a burning sensation and xerostomia. However, the data relating these symptoms to the climacteric require elucidation as there have been no adequately controlled studies. In the present investigation, a group of 145 oöphorectomized women were followed for one year. Approximately half were treated with oestrogen replacement and the remainder with a placebo. The results indicate that the hormone had no direct effect upon the oral symptoms but that there was a general increase in somatic complaints which appeared to be related to the degree of neurosis experienced. This is turn can be attributed to vasomotor changes which are under the control of oestrogen.
许多口腔问题被认为与女性更年期有关，包括味觉改变、烧灼感和口干。然而，由于缺乏充分的对照研究，将这些症状与更年期联系起来的数据仍需阐明。在本研究中，对145名卵巢切除的女性进行了为期一年的跟踪调查。大约一半的女性接受了雌激素替代治疗，其余的则接受安慰剂治疗。结果表明，该激素对口腔症状没有直接影响，但躯体不适普遍增加，这似乎与所经历的神经症程度有关。这反过来又可归因于受雌激素控制的血管舒缩变化。
