长春花生物碱对小鼠抗绵羊红细胞抗体反应的免疫增强作用。
Immunopotentiating effect of vinca alkaloids on the antibody response to sheep red blood cells in the mouse.
作者信息
Byrd J R, Isa A M
出版信息
J Natl Med Assoc. 1981 Aug;73(8):707-9.
Abstract
Evidence is presented that the vinca alkaloids (vinblastine, vincristine, and vindesine) exert an immunopotentiating effect on the antibody response to sheep red blood cells (SRBC). The primary antibody response, measured by the rosette-forming cell (RFC) and hemagglutination (HA) assays, was enhanced by vincristine and vindesine treatments. Neither drug had any effect on the secondary antibody response. Vinblastine, while having no effect on the primary response, augmented the secondary antibody response to SRBC.
摘要
有证据表明，长春花生物碱（长春碱、长春新碱和长春地辛）对针对绵羊红细胞（SRBC）的抗体反应具有免疫增强作用。通过玫瑰花结形成细胞（RFC）和血凝（HA）试验测定的初次抗体反应，在接受长春新碱和长春地辛治疗后得到增强。两种药物对二次抗体反应均无影响。长春碱虽然对初次反应没有影响，但增强了对SRBC的二次抗体反应。
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