Szkaradkiewicz A, Kiczka W
Z Immunitatsforsch Immunobiol. 1978 Sep;154(5):463-70.
The response of peripheral blood leukocytes to purified HBsAg was studied in vitro by means of the leukocyte migration test in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis carrying GBsAg, and in asymptomatic carriers of HBs antigen. In the acute period of the disease no leukocyte migration inhibition could be observed. Patients with chronic aggressive hepatitis also frequently failed to develop cell-mediated immunity to HBsAg. Results obtained for HBs antigen carriers did not differ from those of normal blood donors. The observations may indicate participation of cell-mediated immunity in the development of liver damage.
通过白细胞游走试验，在体外研究了急性乙型病毒性肝炎患者、携带HBsAg的慢性活动性肝炎患者以及无症状HBs抗原携带者外周血白细胞对纯化HBsAg的反应。在疾病急性期未观察到白细胞游走抑制现象。慢性活动性肝炎患者也常常未能产生针对HBsAg的细胞介导免疫。HBs抗原携带者的结果与正常献血者的结果无差异。这些观察结果可能表明细胞介导免疫参与了肝损伤的发生。
