氨苯蝶啶-氢氯噻嗪所致锂中毒
Lithium toxicity induced by triamterene-hydrochlorothiazide.
作者信息
Mehta B R, Robinson B H
出版信息
Postgrad Med J. 1980 Nov;56(661):783-4. doi: 10.1136/pgmj.56.661.783.
Abstract
Two patients on long-term lithium therapy for manic-depressive psychosis developed serious toxicity within days of being prescribed a combination of triamterene (50 mg) and hydrochlorothiazide (25 mg) for mild symptomless hypertension. Reduced clearance of lithium has been reported to follow its concurrent administration with diuretics that deplete both sodium and potassium. A combination of triamterene with thiazide has not been shown previously to precipitate lithium toxicity.
摘要
两名因躁郁症接受长期锂盐治疗的患者，在因轻度无症状高血压而被处方服用氨苯蝶啶（50毫克）和氢氯噻嗪（25毫克）组合药物数天内出现了严重毒性反应。据报道，锂盐与同时使用的排钠排钾利尿剂合用时，锂的清除率会降低。此前尚未发现氨苯蝶啶与噻嗪类药物的组合会引发锂中毒。
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本文引用的文献
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Lithium ion toxicity and pregnancy.锂离子毒性与妊娠
JAMA. 1970 Nov 16;214(7):1325-6.
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Br Med J. 1974 Jul 20;3(5924):143-5. doi: 10.1136/bmj.3.5924.143.
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Treatment of acute lithium intoxication.急性锂中毒的治疗。
Lancet. 1970 Jan 24;1(7639):197-8. doi: 10.1016/s0140-6736(70)90451-4.
4
Letter: Lithium poisoning precipitated by diuretics.信件：利尿剂诱发的锂中毒。
Br Med J. 1975 Mar 1;1(5956):516. doi: 10.1136/bmj.1.5956.516-d.
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