Mehta B R, Robinson B H
Postgrad Med J. 1980 Nov;56(661):783-4. doi: 10.1136/pgmj.56.661.783.
Two patients on long-term lithium therapy for manic-depressive psychosis developed serious toxicity within days of being prescribed a combination of triamterene (50 mg) and hydrochlorothiazide (25 mg) for mild symptomless hypertension. Reduced clearance of lithium has been reported to follow its concurrent administration with diuretics that deplete both sodium and potassium. A combination of triamterene with thiazide has not been shown previously to precipitate lithium toxicity.
两名因躁郁症接受长期锂盐治疗的患者，在因轻度无症状高血压而被处方服用氨苯蝶啶（50毫克）和氢氯噻嗪（25毫克）组合药物数天内出现了严重毒性反应。据报道，锂盐与同时使用的排钠排钾利尿剂合用时，锂的清除率会降低。此前尚未发现氨苯蝶啶与噻嗪类药物的组合会引发锂中毒。
