Schnell R C, Early J L
Res Commun Chem Pathol Pharmacol. 1981 Jun;32(3):561-4.
Three days after pretreatment of rats of both sexes with sodium selenite (2.4 mg Se/kg, ip) the duration of pentobarbital-induced hypnosis was potentiated in males but not females. Similar treatment with selenium led to a significant inhibition of ethylmorphine demethylase activity by hepatic microsomal enzymes obtained from male but not female rats. Selenium treatment did not alter the activity of aniline hydroxylase in animals of either sex. These data show that there is a sex-related difference in the ability of selenium to alter drug response and hepatic drug metabolism, which is substrate-specific, in the rat.
用亚硒酸钠（2.4毫克硒/千克，腹腔注射）对雌雄大鼠进行预处理三天后，戊巴比妥诱导的催眠持续时间在雄性大鼠中增强，但在雌性大鼠中未增强。用硒进行类似处理可显著抑制从雄性而非雌性大鼠获得的肝微粒体酶的乙基吗啡脱甲基酶活性。硒处理未改变两性动物中苯胺羟化酶的活性。这些数据表明，在大鼠中，硒改变药物反应和肝药物代谢的能力存在性别相关差异，且这种差异具有底物特异性。
