Santesson J
Acta Anaesthesiol Scand. 1978;22(4):467-70. doi: 10.1111/j.1399-6576.1978.tb01324.x.
Airway closure measurements were made with the bolus technique on eight healthy subjects, who were in a supine position prior to and during anaesthesia. Measurements were made on an expiration following vital capacity (VC) and 30% VC. Closing volume (CV) was calculated prior to anaesthesia, and closing capacity (CC)--functional residual capacity (FRC) was estimated during anaesthesia. When measured from VC, CV was 703 +/- 20 ml (s.e. mean) and from 30% VC it was 440 +/- 51 ml (s.e. mean) (P less than 0.005) prior to anaesthesia. When measured from VC, CC--FRC was 370 +/- 34 ml (s.e. mean), and from 30% VC it was 343 +/- 37 (s.e. mean) (P greater than 0.05) during anaesthesia. It is concluded that volume history has little effect on CC measurement during anaesthesia and artificial ventilation, but a major influence on CC measurement in the conscious patient. Hence, it is suggested that CC, within the tidal range, is increased during anaesthesia.
采用团注技术对8名健康受试者进行气道闭合测量，这些受试者在麻醉前及麻醉过程中均处于仰卧位。在肺活量（VC）和30%肺活量之后的呼气过程中进行测量。麻醉前计算闭合容积（CV），麻醉期间估算闭合容量（CC）减去功能残气量（FRC）。麻醉前从VC测量时，CV为703±20ml（标准误均值），从30%VC测量时为440±51ml（标准误均值）（P<0.005）。麻醉期间从VC测量时，CC - FRC为370±34ml（标准误均值），从30%VC测量时为343±37（标准误均值）（P>0.05）。得出的结论是，容量变化史对麻醉和人工通气期间的CC测量影响很小，但对清醒患者的CC测量有重大影响。因此，建议在麻醉期间潮气量范围内CC会增加。
