Sanchez R, Sibley R K, Rosai J, Dorfman R F
Ultrastruct Pathol. 1981 Apr-Jun;2(2):101-19. doi: 10.3109/01913128109064239.
Eleven cases of sinus histiocytosis with massive lymphadenopathy (SHML) involving lymph nodes were studied electron microscopically. Histiocytes were the most conspicuous element of the infiltrate. They could be divided into small and large forms, although transitions were apparent among them. Most of the small histiocytes were located in the medullary cords. The large histiocytes were predominantly seen within sinuses and were subdivided into two types on the basis of their appearance. The most distinctive feature of these histiocytes was the presence of lymphocytes, plasma cells, and neutrophils within their cytoplasm. Other cells present in the infiltrate were lymphocytes, plasma cells, and occasional neutrophils and mast cells. Blood vessels were prominent throughout. Virus particles, bacteria, and Langerhans' granules were consistently absent. No morphologic clues were provided by this study as to the etiology of this disorder.
对11例累及淋巴结的伴巨大淋巴结病的窦性组织细胞增生症（SHML）进行了电镜研究。组织细胞是浸润中最显著的成分。它们可分为小细胞型和大细胞型，尽管二者之间有明显的过渡形态。大多数小组织细胞位于髓索。大组织细胞主要见于窦内，并根据其外观细分为两种类型。这些组织细胞最显著的特征是其胞质内存在淋巴细胞、浆细胞和中性粒细胞。浸润中还存在其他细胞，即淋巴细胞、浆细胞，偶尔还有中性粒细胞和肥大细胞。血管在整个病变中都很突出。始终未发现病毒颗粒、细菌和朗格汉斯颗粒。本研究未提供关于该疾病病因的形态学线索。
