Marvola M, Kivirinta R
Acta Pharmacol Toxicol (Copenh). 1978 Nov;43(5):381-6. doi: 10.1111/j.1600-0773.1978.tb02282.x.
Ephedrine has stimulating effects on the CNS which have been shown as increased locomotor activity, for example. No studies on the relationship between this pharmacological effect and blood levels of the drug have been reported. In the present study this question was investigated in mice after intravenous and oral administration of ephedrine. It was concluded that after intravenous injection of ephedrine the blood concentration data fitted best with the two-compartment open model but after oral administration of the drug with the one-compartment model. The locomotor activity stimulating effect of the drug did not have a linear relationship to the drug levels in the central or in the tissue compartment. This suggests that the mechanism of the locomotor activity increasing effect of ephedrine is indirect.
麻黄碱对中枢神经系统有刺激作用，例如表现为运动活性增强。尚未有关于这种药理作用与药物血药浓度之间关系的研究报道。在本研究中，对小鼠静脉注射和口服麻黄碱后对这一问题进行了研究。结果表明，静脉注射麻黄碱后，血药浓度数据最符合二室开放模型，而口服该药物后则符合一室模型。该药物的运动活性刺激作用与中枢或组织室中的药物水平没有线性关系。这表明麻黄碱增加运动活性作用的机制是间接的。
