May C S, Pickup M E, Paterson J W
Br J Clin Pharmacol. 1975 Dec;2(6):533-7. doi: 10.1111/j.1365-2125.1975.tb00572.x.
In eight asthmatic patients, there was no change in the bronchodilator response to a single dose of ephedrine (22 mg) given alone or in a compound tablet, after treatment with ephedrine (11 mg three times a day) or one tablet three times a day for 2 weeks. 2 There was no deterioration in lung function during the 2 week treatment period with either ephedrine or the compound tablet. 3 An inter-patient variation was noted in the plasma ephedrine concentraition required for bronchodilatation. 4 The half-life of theophylline did not change after chronic treatment with the tablets, one three times a day for 2 weeks.
在8名哮喘患者中，在用麻黄碱（每日3次，每次11毫克）或复方片剂每日3次治疗2周后，单独给予单剂量麻黄碱（22毫克）或复方片剂时，支气管扩张剂反应无变化。2在用麻黄碱或复方片剂治疗的2周期间，肺功能没有恶化。3在支气管扩张所需的血浆麻黄碱浓度方面，观察到患者间存在差异。4在用片剂每日3次、持续2周进行长期治疗后，茶碱的半衰期没有改变。
