Tomova I, Taskov M
Acta Physiol Pharmacol Bulg. 1978;4(1):42-8.
The vascular action of crataemon is studied. The effect of the drug on organ blood flow is examined using isotope methods. It is established that under conditions of blood loss, 10 mg/kg crataemon sharply inceases the blood supply to the myocardium and liver. Under the same conditions the blood flow in the kidneys and intestines decreases after administration of the drug. Its effect is weaker in case of normal blood pressure. In the case of perfusion of cat hind legs the flavonoid mixture studied has a biphasic effect manifested in the form of initial brief hypertension, followed by a more prolonged and stronger depressor reaction. In larger oral doses (100 and 200 mg/kg) crataemon increases the resistance of the capillaries and decreases capillary permeability in albino rats. The experiments carried out confirm the predominantly action of crataemon on some vascular regions (heart and liver). It has biphasic effect on peripheral vessels, which may be attributed to the presence of different components. The capillary-tonic action is most probably due to the presence of rutin and rutin-like flavonoids.
对山楂叶总黄酮的血管作用进行了研究。采用同位素方法检测了该药物对器官血流的影响。结果表明，在失血情况下，10mg/kg山楂叶总黄酮能显著增加心肌和肝脏的血液供应。在相同条件下，给药后肾脏和肠道的血流量减少。在血压正常的情况下，其作用较弱。在灌注猫后肢时，所研究的黄酮类混合物具有双相作用，表现为初始短暂的高血压，随后是更持久、更强的降压反应。大剂量口服（100和200mg/kg）山楂叶总黄酮可增加白化大鼠毛细血管的阻力并降低毛细血管通透性。所进行的实验证实了山楂叶总黄酮对某些血管区域（心脏和肝脏）具有主要作用。它对外周血管有双相作用，这可能归因于其不同成分的存在。毛细血管张力作用很可能是由于芦丁和类芦丁黄酮的存在。
