Marichy J, Lasne J, Roussel A, Goudot B, Romero S, Chauvet H, Banssillon V G
Anesth Analg (Paris). 1981;38(5-6):223-5.
Circadian rhythms of cortisol were studied in 10 patients. This study was made shortly after the burn and for a short period of one or two days maximum in 9 patients. Blood level measurements of cortisone were made in 4 patients. 7 patients died. The analysis of circadian rhythm was made with a computer (méthode de régression harmonique combinée à une analyse de variance). The results are deceiving: there are qualitative and quantitative disturbances but we could not give a significance to them, each patient reacting differently. In one case, a drop of cortisol to 0 was observed and the patient died, this observation shows the development of corticosurrenal failure. So, one or several measurements do not allow the study of corticosurrenal function which differs in each case. Theoretical appreciations in handbooks on the subject must be tempered.
对10名患者的皮质醇昼夜节律进行了研究。这项研究在烧伤后不久进行，9名患者最长持续了一两天的短时间。对4名患者进行了可的松的血药浓度测量。7名患者死亡。采用计算机（谐波回归法结合方差分析）进行昼夜节律分析。结果令人困惑：存在定性和定量的紊乱，但我们无法确定其显著性，因为每个患者的反应都不同。在一个病例中，观察到皮质醇降至0，患者死亡，这一观察结果表明肾上腺皮质功能衰竭的发生。因此，单次或几次测量无法研究肾上腺皮质功能，因为每种情况都不同。关于该主题的手册中的理论评估必须谨慎对待。
