Strout C D, Nahrwold M L
Anesthesiology. 1981 Sep;55(3):322-3. doi: 10.1097/00000542-198109000-00024.
Near-term pregnancy is associated with a decrease in the minimum alveolar concentration (MAC) for halothane in ewes. Although increased progesterone levels might account for this change, a correlation between MAC and the known variations of progesterone levels which occur throughout gestation and the postpartum period has not been performed. Therefore, MAC for halothane was determined in nonpregnant, 10 days pregnant, term, and postpartum lactating rats. MAC values were significantly decreased by 19 per cent on the tenth day of pregnancy, and by 16 per cent at term, but they returned to control values 5 days postpartum. These changes did not correlate with the known changes in progesterone levels during pregnancy and lactation, and the authors conclude that progesterone is not responsible for the reduction in halothane MAC.
接近足月妊娠与母羊氟烷最低肺泡浓度（MAC）降低有关。尽管孕酮水平升高可能是这种变化的原因，但尚未对MAC与整个妊娠期和产后孕酮水平的已知变化之间的相关性进行研究。因此，测定了未怀孕、怀孕10天、足月和产后哺乳大鼠的氟烷MAC。怀孕第10天MAC值显著降低19%，足月时降低16%，但产后5天恢复到对照值。这些变化与妊娠和哺乳期孕酮水平的已知变化无关，作者得出结论，孕酮不是氟烷MAC降低的原因。
