氟烷、异氟烷和安氟醚在怀孕及未怀孕的雌性和雄性小鼠及大鼠中的最低肺泡有效浓度。
Halothane, isoflurane, and enflurane MAC in pregnant and nonpregnant female and male mice and rats.
作者信息
Mazze R I, Rice S A, Baden J M
出版信息
Anesthesiology. 1985 Mar;62(3):339-41. doi: 10.1097/00000542-198503000-00021.
The MAC of halothane, isoflurane, and enflurane was determined using the tail-clamp technique in pregnant female, nonpregnant female, and male Swiss Webster mice (n = 216) and Sprague-Dawley rats (n = 112). Mean MAC values (+/-SD) for halothane, isoflurane, and enflurane in mice were 0.95 +/- 0.07%, 1.34 +/- 0.10%, and 1.95 +/- 0.16%, respectively; values in rats were 1.03 +/- 0.04%, 1.46 +/- 0.06%, and 2.21 +/- 0.08%, respectively, all significantly higher than in mice. Neither the sex of the animals nor whether female animals were pregnant influenced the results.
采用尾夹法测定了怀孕雌性、未怀孕雌性和雄性瑞士韦伯斯特小鼠（n = 216）以及斯普拉格-道利大鼠（n = 112）中氟烷、异氟烷和恩氟烷的最低肺泡有效浓度（MAC）。小鼠中氟烷、异氟烷和恩氟烷的平均MAC值（±标准差）分别为0.95±0.07%、1.34±0.10%和1.95±0.16%；大鼠中的值分别为1.03±0.04%、1.46±0.06%和2.21±0.08%，均显著高于小鼠。动物的性别以及雌性动物是否怀孕均未影响结果。
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