Mazze R I, Rice S A, Baden J M
Anesthesiology. 1985 Mar;62(3):339-41. doi: 10.1097/00000542-198503000-00021.
The MAC of halothane, isoflurane, and enflurane was determined using the tail-clamp technique in pregnant female, nonpregnant female, and male Swiss Webster mice (n = 216) and Sprague-Dawley rats (n = 112). Mean MAC values (+/-SD) for halothane, isoflurane, and enflurane in mice were 0.95 +/- 0.07%, 1.34 +/- 0.10%, and 1.95 +/- 0.16%, respectively; values in rats were 1.03 +/- 0.04%, 1.46 +/- 0.06%, and 2.21 +/- 0.08%, respectively, all significantly higher than in mice. Neither the sex of the animals nor whether female animals were pregnant influenced the results.
采用尾夹法测定了怀孕雌性、未怀孕雌性和雄性瑞士韦伯斯特小鼠（n = 216）以及斯普拉格-道利大鼠（n = 112）中氟烷、异氟烷和恩氟烷的最低肺泡有效浓度（MAC）。小鼠中氟烷、异氟烷和恩氟烷的平均MAC值（±标准差）分别为0.95±0.07%、1.34±0.10%和1.95±0.16%；大鼠中的值分别为1.03±0.04%、1.46±0.06%和2.21±0.08%，均显著高于小鼠。动物的性别以及雌性动物是否怀孕均未影响结果。
