慢性活动性肝炎中针对兔肝细胞的直接及血清诱导淋巴细胞毒性作用
Direct and serum-induced lymphocytotoxicity against rabbit hepatocytes in chronic active hepatitis.
作者信息
Ortona L, Laghi V, Cauda R, Nervo P
出版信息
Boll Ist Sieroter Milan. 1981;60(1):46-51.
The direct and the serum-induced lymphocytotoxicity against cultured rabbit hepatocytes were evaluated in 25 patients with chronic active hepatitis (CAH) (15 HBsAg+). Twelve out of fifteen HBsAg+ and nine out of ten HBsAg- patients have shown an increased cytotoxicity for rabbit hepatocytes. Moreover the sera of the same patients were able to induce a significant cytotoxicity in normal lymphocytes against rabbit hepatocytes. The addition of LSP was able to inhibit the cytotoxic reaction for rabbit hepatocytes in all cases with positive cytotoxic index. Indeed, the results we have obtained are the following. a) A significant lymphocytotoxicity for rabbit hepatocytes exists in patients with CAH, and this is unrelated to HBsAg status. b) A linear correlation ( r = 0.88; p less than 0.001) exists between the direct and the serum-induced lymphocytotoxicity in CAH hepatitis. c) The cytotoxicity to rabbit hepatocytes seems to be an antibody mediated process and the target antigen seems to be LSP.
对25例慢性活动性肝炎（CAH）患者（其中15例HBsAg阳性）进行了针对培养兔肝细胞的直接淋巴细胞毒性和血清诱导淋巴细胞毒性评估。15例HBsAg阳性患者中的12例以及10例HBsAg阴性患者中的9例对兔肝细胞的细胞毒性增加。此外，相同患者的血清能够在正常淋巴细胞中诱导出针对兔肝细胞的显著细胞毒性。在所有细胞毒性指数为阳性的病例中，添加脂多糖（LSP）能够抑制针对兔肝细胞的细胞毒性反应。实际上，我们得到的结果如下：a）CAH患者中存在对兔肝细胞的显著淋巴细胞毒性，且这与HBsAg状态无关。b）在CAH肝炎中，直接淋巴细胞毒性和血清诱导淋巴细胞毒性之间存在线性相关性（r = 0.88；p小于0.001）。c）对兔肝细胞的细胞毒性似乎是一个抗体介导的过程，且靶抗原似乎是LSP。
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