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慢性活动性肝炎患者兔肝特异性脂蛋白（RLSP）淋巴细胞转化试验

Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

作者信息

Ortona L, Laghi V, Cauda R, Nervo P

出版信息

Clin Exp Immunol. 1979 Nov;38(2):231-4.

PMID:527260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537866/
Abstract

Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg negative) while values were lower than 2 in all the normal subjects. These results confirm the finding of sensitization to LSP in chronic active hepatitis irrespective of HBsAg status and show that rabbit LSP can be used as an alternative to the human antigen in the lymphocyte transformation test, and is further evidence that this liver membrane lipoprotein has antigenic determinants which have species-cross-reactivity.

摘要

在慢性活动性肝炎（CAH）患者中，已通过淋巴细胞转化试验研究了细胞对兔肝特异性脂蛋白（RLSP）的致敏作用。25例患者中有20例（10例HBsAg阳性患者中的8例以及15例HBsAg阴性患者中的12例）的刺激指数大于2，而所有正常受试者的刺激指数均低于2。这些结果证实了无论HBsAg状态如何，慢性活动性肝炎患者均存在对LSP的致敏现象，表明兔LSP可在淋巴细胞转化试验中用作人类抗原的替代品，进一步证明这种肝细胞膜脂蛋白具有种属交叉反应性的抗原决定簇。

相似文献

1
Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.慢性活动性肝炎患者兔肝特异性脂蛋白（RLSP）淋巴细胞转化试验
Clin Exp Immunol. 1979 Nov;38(2):231-4.
2
Immune response to rabbit liver-specific lipoprotein in acute viral hepatitis.急性病毒性肝炎中对兔肝特异性脂蛋白的免疫反应。
Clin Exp Immunol. 1980 Dec;42(3):436-40.
3
Incidence of antibodies against rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.慢性活动性肝炎中抗兔肝特异性脂蛋白（RLSP）抗体的发生率。
Clin Exp Immunol. 1983 May;52(2):437-40.
4
Direct and serum-induced lymphocytotoxicity against rabbit hepatocytes in chronic active hepatitis.慢性活动性肝炎中针对兔肝细胞的直接及血清诱导淋巴细胞毒性作用
Boll Ist Sieroter Milan. 1981;60(1):46-51.
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[Direct and induced lymphocytotoxicity to rabbit hepatocytes in chronic active hepatitis].[慢性活动性肝炎中对兔肝细胞的直接和诱导淋巴细胞毒性]
Arch Sci Med (Torino). 1980 Oct-Dec;137(4):575-7.
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LM-Ag and LSP--two different target antigens involved in the immunopathogenesis of chronic active hepatitis?肝细胞膜抗原和肝特异性脂蛋白——两种参与慢性活动性肝炎免疫发病机制的不同靶抗原？
Clin Exp Immunol. 1979 Aug;37(2):205-12.
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Inhibition of lymphocyte cytotoxicity in chronic active hepatitis.慢性活动性肝炎中淋巴细胞细胞毒性的抑制作用。
Clin Exp Immunol. 1978 Jul;33(1):71-8.
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Immunological reactions to liver-specific membrane lipoprotein (LSP) in experimental autoimmune liver disease in rabbits.兔实验性自身免疫性肝病中对肝脏特异性膜脂蛋白（LSP）的免疫反应。
Clin Exp Immunol. 1982 May;48(2):505-12.
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Occurrence and significance of antibody to liver-specific membrane lipoprotein by double-antibody immunoprecipitation method in sera of patients with acute and chronic liver diseases.用双抗体免疫沉淀法检测急慢性肝病患者血清中肝特异性膜脂蛋白抗体的发生情况及意义
Gastroenterology. 1979 Apr;76(4):665-72.
10
Lymphocyte transformation test with liver-specific protein and phytohaemagglutinin in patients with liver disease.肝病患者肝脏特异性蛋白和植物血凝素的淋巴细胞转化试验
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引用本文的文献

1
Histological and immunological investigation of liver-specific protein (LSP) immunized rabbits compared with patients with liver disease.将肝特异性蛋白（LSP）免疫的兔子与肝病患者进行比较的组织学和免疫学研究。
Clin Exp Immunol. 1981 Jul;45(1):143-51.
2
Incidence of antibodies against rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.慢性活动性肝炎中抗兔肝特异性脂蛋白（RLSP）抗体的发生率。
Clin Exp Immunol. 1983 May;52(2):437-40.
3
Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non-A, non-B.甲型、乙型和非甲非乙型急慢性病毒性肝炎患者体内抗人肝脏特异性蛋白（LSP）抗体
Clin Exp Immunol. 1981 Nov;46(2):382-90.
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Study of cellular immunity in experimental autoimmune hepatitis in mice.小鼠实验性自身免疫性肝炎的细胞免疫研究
Clin Exp Immunol. 1984 Jul;57(1):85-92.
5
Study of cellular immunity in experimental autoimmune hepatitis in mice: transfer of spleen cells sensitized with liver proteins.小鼠实验性自身免疫性肝炎的细胞免疫研究：用肝脏蛋白致敏的脾细胞转移
Clin Exp Immunol. 1985 Sep;61(3):577-84.
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Immunological aspects of chronic active hepatitis.慢性活动性肝炎的免疫学方面
Clin Exp Immunol. 1987 May;68(2):225-32.
7
Relationship between general or specific immunoreactivity and prognosis in postoperative patients with hepatocellular carcinoma.肝细胞癌术后患者的一般或特异性免疫反应性与预后的关系。
Cancer Immunol Immunother. 1990;31(2):107-14. doi: 10.1007/BF01742374.

本文引用的文献

1
Cell-mediated immune responses in chronic liver diseases.慢性肝病中的细胞介导免疫反应。
Br Med J. 1972 Feb 26;1(5799):527-30. doi: 10.1136/bmj.1.5799.527.
2
[Cellular immune reactions towards homologous liver-specific antigens (HLP) in chronic inflammatory liver diseases (author's transl)].慢性炎症性肝病中针对同源肝脏特异性抗原（HLP）的细胞免疫反应（作者译）
Klin Wochenschr. 1974 Mar 1;52(5):246-8. doi: 10.1007/BF01468598.
3
Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis.慢性活动性肝炎中淋巴细胞对分离肝细胞的细胞毒性。
Nature. 1974 Dec 20;252(5485):721-2. doi: 10.1038/252721a0.
4
Experimental chronic active hepatitis in rabbits following immunization with human liver proteins.用人肝蛋白质免疫家兔后实验性慢性活动性肝炎
Clin Exp Immunol. 1972 May;11(1):99-108.
5
A classification of chronic hepatitis.慢性肝炎的一种分类
Lancet. 1968 Sep 14;2(7568):626-8. doi: 10.1016/s0140-6736(68)90710-1.
6
Liver-specific antigens of different species. II. Localization of a membrane antigen at cell surface of isolated hepatocytes.不同物种的肝脏特异性抗原。II. 一种膜抗原在分离的肝细胞表面的定位。
Clin Exp Immunol. 1974 Jan;16(1):117-23.
7
Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis.在活动性慢性肝炎发展过程中，对乙肝表面抗原的抗体反应不足或存在抑制性T细胞缺陷。
Lancet. 1974 Dec 28;2(7896):1543-5. doi: 10.1016/s0140-6736(74)90287-6.
8
Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis.活动性慢性肝炎和原发性胆汁性肝硬化患者对一种人肝脏特异性抗原的细胞介导免疫。
Lancet. 1972 Aug 12;2(7772):296-7. doi: 10.1016/s0140-6736(72)92904-2.
9
Immunological studies in patients with chronic active hepatitis. Cytotoxic activity of lymphocytes to autochthonous liver cells grown in tissue culture.慢性活动性肝炎患者的免疫学研究。淋巴细胞对组织培养中生长的自身肝细胞的细胞毒性活性。
Clin Exp Immunol. 1975 Jan;19(1):99-104.
10
Cellular and humoral immunity to hepatitis-B surface antigen in active chronic hepatitis.慢性活动性肝炎中针对乙型肝炎表面抗原的细胞免疫和体液免疫
Br Med J. 1975 Mar 29;1(5960):705-8. doi: 10.1136/bmj.1.5960.705.