慢性活动性肝炎患者兔肝特异性脂蛋白（RLSP）淋巴细胞转化试验
Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.
作者信息
Ortona L, Laghi V, Cauda R, Nervo P
出版信息
Clin Exp Immunol. 1979 Nov;38(2):231-4.
Abstract
Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg negative) while values were lower than 2 in all the normal subjects. These results confirm the finding of sensitization to LSP in chronic active hepatitis irrespective of HBsAg status and show that rabbit LSP can be used as an alternative to the human antigen in the lymphocyte transformation test, and is further evidence that this liver membrane lipoprotein has antigenic determinants which have species-cross-reactivity.
摘要
在慢性活动性肝炎（CAH）患者中，已通过淋巴细胞转化试验研究了细胞对兔肝特异性脂蛋白（RLSP）的致敏作用。25例患者中有20例（10例HBsAg阳性患者中的8例以及15例HBsAg阴性患者中的12例）的刺激指数大于2，而所有正常受试者的刺激指数均低于2。这些结果证实了无论HBsAg状态如何，慢性活动性肝炎患者均存在对LSP的致敏现象，表明兔LSP可在淋巴细胞转化试验中用作人类抗原的替代品，进一步证明这种肝细胞膜脂蛋白具有种属交叉反应性的抗原决定簇。
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本文引用的文献
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Cell-mediated immune responses in chronic liver diseases.慢性肝病中的细胞介导免疫反应。
Br Med J. 1972 Feb 26;1(5799):527-30. doi: 10.1136/bmj.1.5799.527.
2
[Cellular immune reactions towards homologous liver-specific antigens (HLP) in chronic inflammatory liver diseases (author's transl)].慢性炎症性肝病中针对同源肝脏特异性抗原（HLP）的细胞免疫反应（作者译）
Klin Wochenschr. 1974 Mar 1;52(5):246-8. doi: 10.1007/BF01468598.
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Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis.慢性活动性肝炎中淋巴细胞对分离肝细胞的细胞毒性。
Nature. 1974 Dec 20;252(5485):721-2. doi: 10.1038/252721a0.
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Experimental chronic active hepatitis in rabbits following immunization with human liver proteins.用人肝蛋白质免疫家兔后实验性慢性活动性肝炎
Clin Exp Immunol. 1972 May;11(1):99-108.
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A classification of chronic hepatitis.慢性肝炎的一种分类
Lancet. 1968 Sep 14;2(7568):626-8. doi: 10.1016/s0140-6736(68)90710-1.
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Liver-specific antigens of different species. II. Localization of a membrane antigen at cell surface of isolated hepatocytes.不同物种的肝脏特异性抗原。II. 一种膜抗原在分离的肝细胞表面的定位。
Clin Exp Immunol. 1974 Jan;16(1):117-23.
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Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis.在活动性慢性肝炎发展过程中，对乙肝表面抗原的抗体反应不足或存在抑制性T细胞缺陷。
Lancet. 1974 Dec 28;2(7896):1543-5. doi: 10.1016/s0140-6736(74)90287-6.
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Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis.活动性慢性肝炎和原发性胆汁性肝硬化患者对一种人肝脏特异性抗原的细胞介导免疫。
Lancet. 1972 Aug 12;2(7772):296-7. doi: 10.1016/s0140-6736(72)92904-2.
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Cellular and humoral immunity to hepatitis-B surface antigen in active chronic hepatitis.慢性活动性肝炎中针对乙型肝炎表面抗原的细胞免疫和体液免疫
Br Med J. 1975 Mar 29;1(5960):705-8. doi: 10.1136/bmj.1.5960.705.
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