Ukikusa M, Kamiyama Y, Sato T, Tanaka J, Jones R T, Cowley R A, Trump B F
Circ Shock. 1981;8(4):483-90.
Changes in energy metabolism of rat liver in hemorrhagic shock were investigated. The hepatic energy charge level (0.24-0.693) correlated significantly with the mean arterial blood pressure (20-75 mmHg) (r = 0.931, P less than 0.001), as well as the blood volume withdrawn (2.43-2.82 ml/100 g body weight) which, in turn, correlated with the various mortality rates (LD16, LD50, and LD84) (r = -0.728, P less than 0.01). As shown by the changes in adenylate energy charge levels, the liver was very sensitive to acute blood loss. There was no significant difference between the energy charge levels of liver obtained in situ from rats with 84% mortality after hemorrhage and that of the same liver further incubated in vitro in the absence of O2 (0.304 versus 0.235). From these results, it appears that the energy status in the liver of rats dying from severe hemorrhagic shock has changed to anaerobic metabolism, which may not be sufficient to maintain adequate liver function or support individual survival.
研究了失血性休克大鼠肝脏能量代谢的变化。肝脏能量电荷水平（0.24 - 0.693）与平均动脉血压（20 - 75 mmHg）显著相关（r = 0.931，P < 0.001），同时也与失血量（2.43 - 2.82 ml/100 g体重）相关，而失血量又与不同死亡率（LD16、LD50和LD84）相关（r = -0.728，P < 0.01）。从腺苷酸能量电荷水平的变化可以看出，肝脏对急性失血非常敏感。出血后死亡率为84%的大鼠原位肝脏的能量电荷水平与同一肝脏在无氧气条件下进一步体外孵育后的能量电荷水平之间无显著差异（0.304对0.235）。从这些结果来看，死于严重失血性休克的大鼠肝脏能量状态已转变为无氧代谢，这可能不足以维持肝脏的正常功能或支持个体存活。
