McCarron M M, Gaddis G P, Trotter A T
Clin Toxicol. 1981 Jun;18(6):693-711. doi: 10.3109/15563658108990295.
Ten cases of ingestion of yellow phosphorus rat poison, including four cases that occurred during the past 3 years, are reported. Comparison of these cases with 82 others from the literature showed that ingestion of yellow phosphorus paste often results in clinical findings that are different from those described for acute yellow phosphorus poisoning in current toxicology texts. The time lag between swallowing of the poison and onset of symptoms varied from a few minutes to 24 h. Garlic odor, mucosal burns, and phosphorescent vomitus or feces occurred in only a small percentage of cases. Diarrhea was not a presenting complaint. Initial symptoms were referable to the gastrointestinal tract, central nervous system, or both. Mortality rates were 23% for patients who had early symptoms of vomiting or abdominal pain; 73% for those where the first manifestation of intoxication was restlessness, irritability, drowsiness, stupor, or coma; and 47% for patients who had a combination of these GI and CNS symptoms initially. Applying standard diagnostic criteria for yellow phosphorus poisoning to patients who have consumed yellow phosphorus pastes may result in serious diagnostic errors.
本文报告了10例摄入黄磷鼠药的病例,其中4例发生在过去3年。将这些病例与文献中其他82例病例进行比较发现,摄入黄磷糊剂后的临床症状往往与当前毒理学文献中描述的急性黄磷中毒症状不同。吞服毒物至症状出现的时间间隔从几分钟到24小时不等。仅有一小部分病例出现大蒜气味、黏膜灼伤以及呕吐物或粪便发磷光的情况。腹泻并非首发症状。初始症状涉及胃肠道、中枢神经系统或两者。出现呕吐或腹痛等早期症状的患者死亡率为23%;中毒首发表现为烦躁不安、易怒、嗜睡、昏迷或昏迷的患者死亡率为73%;最初同时出现胃肠道和中枢神经系统症状的患者死亡率为47%。对摄入黄磷糊剂的患者应用黄磷中毒的标准诊断标准可能会导致严重的诊断错误。