Mochizuki Y, Furukawa K, Sawada N, Gotoh M
Gan. 1981 Feb;72(1):170-3.
Sequential feeding of various dose levels of phenobarbital (PB) after diethylnitrosamine (DENA) administration revealed that the enhancing effect of PB on hepatocarcinogenesis was dose-dependent. The highest dose level of PB, 0.2% in the diet, greatly enhanced the formation of tumors larger than 5mm in diameter. Tumors obtained in the 0.2% PB feeding group were more numerous and larger in size than those in th 0.01, 0.05, and 0.1% PB feeding groups. although it took longer, the enhancing effect of 0.01% PB feeding was evident when DENA had been administered for 3 weeks, while the same dose level of PB clearly enhanced hepatocarcinogenesis when the carcinogen had been given for 5 weeks.
在给予二乙基亚硝胺（DENA）后，连续投喂不同剂量水平的苯巴比妥（PB），结果显示PB对肝癌发生的增强作用呈剂量依赖性。饮食中PB的最高剂量水平（0.2%）极大地促进了直径大于5毫米的肿瘤形成。0.2% PB投喂组获得的肿瘤比0.01%、0.05%和0.1% PB投喂组的肿瘤数量更多、体积更大。尽管所需时间更长，但当DENA给药3周时，0.01% PB投喂的增强作用很明显，而当致癌物给药5周时，相同剂量水平的PB明显增强了肝癌发生。
