Tsuno T, Konishi M, Naito T, Kawaguchi H
J Antibiot (Tokyo). 1981 Apr;34(4):390-402. doi: 10.7164/antibiotics.34.390.
Structures of glysperins A, B and C were determined on the basis of chemical degradation studies in conjunction with spectroscopic analyses. Glysperin A consisted of L-alanine, p-hydroxybenzoic acid, a C11-alkyl tetramine and four sugar moieties, three of which were identified as D-ribose, D-galactose and 2,4-diamino-2,4,6-trideoxy-D-galactose. The fourth sugar was a novel exoenose, 6-deoxy-D-xylo-hex-5-enose. Structural difference between glysperins A and B resided solely in the terminal polyamine moiety which was spermidine in glysperin B. Glysperin C contained D-glucose in place of the exoenohexose moiety of glysperin A. Glysperins A, B and C are, in some respects, structurally related to the glycocinnamoylspermidine antibiotics, LL-BM 123 beta, gamma 1 and gamma 2.
基于化学降解研究并结合光谱分析确定了格利斯菌素A、B和C的结构。格利斯菌素A由L-丙氨酸、对羟基苯甲酸、一种C11烷基四胺和四个糖部分组成，其中三个被鉴定为D-核糖、D-半乳糖和2,4-二氨基-2,4,6-三脱氧-D-半乳糖。第四个糖是一种新型的外烯糖，6-脱氧-D-木糖-己-5-烯糖。格利斯菌素A和B之间的结构差异仅存在于末端多胺部分，格利斯菌素B中的末端多胺部分是亚精胺。格利斯菌素C含有D-葡萄糖，取代了格利斯菌素A的外烯己糖部分。在某些方面，格利斯菌素A、B和C在结构上与糖肉桂酰亚精胺抗生素LL-BM 123 β、γ1和γ2相关。
