Dinsmore C E
J Exp Zool. 1977 Feb;199(2):163-75. doi: 10.1002/jez.1401990202.
Regeneration of the tail in the plethodontid salamander, Plethodon cinereus, occurs following either surgical amputation or induced autotomy. Autotomy may occur along any one of the caudal myosepta which form natural cleavage planes. The distally attached myofibers break away from the myoseptum which then becomes part of the stump surface remaining intact during subsequent regeneration of the distal segments. Under these conditions, therefore, muscle fibers do not normally participate in tail regeneration. If, however, the myofibers of a caudal myotome are interrupted as in mid-segment amputation, the damaged fibers undergo hyaline degeneration and are largely replaced by connective tissue often as far proximally as the next myoseptum. Other tissues at the amputation surface are concurrently engaged in the epimorphic regeneration of the tail, including myogenesis, though at a slower initial rate than that following autotomy. Muscle cells, therefore, appear not to participate in epimorphic tail regeneration in Plethodon cinereus following either surgical amputation or induced autotomy.
在无肺螈科蝾螈红背无肺螈中，尾巴的再生在手术截肢或诱导自切后都会发生。自切可能沿着形成自然分裂平面的任何一个尾肌隔发生。远端附着的肌纤维从肌隔分离，然后肌隔成为残端表面的一部分，在远端节段随后的再生过程中保持完整。因此，在这些情况下，肌纤维通常不参与尾巴再生。然而，如果尾肌节的肌纤维像在中段截肢那样被中断，受损的纤维会发生透明变性，并在很大程度上被结缔组织取代，结缔组织通常会一直延伸到近端的下一个肌隔。截肢表面的其他组织同时参与尾巴的形态发生再生，包括肌生成，尽管初始速度比自切后要慢。因此，无论是手术截肢还是诱导自切后，肌肉细胞似乎都不参与红背无肺螈尾巴的形态发生再生。
