Ito T
J Toxicol Sci. 1981 May;6(2):83-103. doi: 10.2131/jts.6.83.
The oral administration of CCl4 (2.5 ml/kg) to male rats inducted increase in the activity of serum GPT, accumulation of hepatic triglyceride, acceleration of depression in the activities of microsomal enzymes, disaggregation of hepatic polyribosomes, and decrease in the ability of in vitro protein synthesis 0.5 hr after the intubation. When, however, a small dose of CCl4 (0.25 ml/kg) were given, the defects in hepatic polyribosomes and mixed-function oxygenase system were most marked among the above toxic changes.
给雄性大鼠经口给予四氯化碳（2.5毫升/千克），在插管后0.5小时，血清谷丙转氨酶活性升高、肝甘油三酯蓄积、微粒体酶活性抑制加速、肝多核糖体解聚以及体外蛋白质合成能力下降。然而，当给予小剂量四氯化碳（0.25毫升/千克）时，在上述毒性变化中，肝多核糖体和混合功能氧化酶系统的缺陷最为明显。
