Hewitt C B, Babiszewski J F, Antunez A R
J Urol. 1981 Sep;126(3):323-5. doi: 10.1016/s0022-5347(17)54507-3.
A 15-year experience with intracavitary radiation for the treatment of selected bladder tumors is presented. The age range of these patients was 39 to 91 years, with an average of 65 years. There were 38 men and 17 women with multiple stage A bladder tumors and carcinoma in situ. Some patients were poor risks for treatment by total extirpative surgery. A simplified technique using a 25 mg. radium capsule as a central source is described for administration of 4,000 to 5,000 rad to the surface of the bladder. Most patients tolerate the presence of the radium catheter with little difficulty. No morbidity and no mortality were reported. In this series more than 60 per cent of the patients benefited from the therapy, with no recurrence noted in some cases after up to 8 1/2 years of followup. Intracavitary radiation is used in few clinics. Use of this modality does not preclude or complicate the subsequent use of other conservative measures or radical therapy if required. It is an effective procedure for treatment of multiple superficial and noninvasive tumors, including primary or recurrent carcinoma in situ, that are uncontrolled by other conservative measures.
本文介绍了15年来采用腔内放射治疗特定膀胱肿瘤的经验。这些患者的年龄在39岁至91岁之间，平均年龄为65岁。其中有38名男性和17名女性，患有多发A期膀胱肿瘤及原位癌。部分患者因全身状况差而不宜接受根治性手术治疗。本文描述了一种简化技术，即使用一颗25毫克镭胶囊作为中心源，对膀胱表面给予4000至5000拉德的辐射剂量。大多数患者对镭管的留置耐受良好，未出现并发症及死亡病例。在该系列研究中，超过60%的患者从该治疗中获益，部分病例在长达8年半的随访期内未见复发。腔内放射治疗仅在少数诊所应用。采用这种治疗方式并不妨碍后续必要时使用其他保守治疗措施或根治性治疗，也不会使其变得复杂。对于多种浅表性和非浸润性肿瘤，包括原发性或复发性原位癌，若其他保守治疗措施无法控制，腔内放射治疗是一种有效的治疗方法。
