Miserocchi G, Nakamura T, Agostoni E
Respir Physiol. 1981 Mar;43(3):197-208. doi: 10.1016/0034-5687(81)90102-x.
Simultaneous measurements of pleural surface (Ppl) and liquid (Pliq) pressures were made at various lung heights in lateral and supine dogs on increasing lung volume from FRC to 80% TLC by decreasing abdominal pressure. The difference between Pliq and Ppl, /Pdef liq/, i.e. the pressure elicited by the deformation forces of the contacting pleurae over the areas of intervening liquid, was greater in the superior parts at all lung volumes. Previous data on pleural liquid thickness (9) and the present measurements show that an increase of /Pdef liq/ may occur either with a decrease or an increase of 9. delta Pdef liq/delta Ppl over a given range of Ppl, increases progressively from bottom up. For a given height the greater the initial /Pdef liq/, the greater delta Pdef liq/delta Ppl. When /Pdef liq/ was decreased by injecting liquid into the pleural space at FRC, delta Pdef liq/delta Ppl decreased. Hence, delta Pdef liq/delta Ppl depends on the initial Pdef liq, i.e. upon the initial tightness of fitting of the pleural membranes. A model interpretation of this relationship is provided.
通过降低腹部压力使侧卧位和仰卧位犬的肺容积从功能残气量（FRC）增加至肺总量（TLC）的80%，在不同肺高度同时测量胸膜表面压力（Ppl）和胸腔内液体压力（Pliq）。在所有肺容积下，胸腔内液体与胸膜表面之间的压力差，即/Pdef liq/，也就是在介入液体区域上接触胸膜的变形力所引发的压力，在上部区域更大。先前关于胸膜液体厚度的数据（9）以及当前的测量结果表明，/Pdef liq/的增加可能伴随胸膜液体厚度的减小或增加。在给定的Ppl范围内，/Pdef liq/相对于Ppl的变化率（delta Pdef liq/delta Ppl）从下往上逐渐增大。对于给定高度，初始/Pdef liq/越大，delta Pdef liq/delta Ppl越大。当在功能残气量时向胸腔内注入液体使/Pdef liq/降低时，delta Pdef liq/delta Ppl减小。因此，delta Pdef liq/delta Ppl取决于初始Pdef liq，即取决于胸膜膜初始贴合的紧密程度。本文提供了这种关系的模型解释。
