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[自身免疫性疾病中不饱和转钴胺素II的升高:红斑狼疮和皮肌炎的过程研究]

[Elevation of unsaturated transcobalamin II in autoimmune diseases: study of the process in lupus erythematosis and dermatomyositis].

作者信息

Fràter-Schröder M, Leumann E, Grob P J, Hitzig W H

出版信息

Schweiz Med Wochenschr. 1980 Oct 4;110(40):1441-3.

PMID:7280591
Abstract

In an earlier study concerning patients with autoimmune diseases, a more reliable correlation of clinical disease activity was found with raised concentrations of the serum protein transcobalamin II than with several tests now in common use (complement factor C3, antinuclear antibody titer and antinative DNA binding capacity). These findings were subsequently confirmed in long-term observations over 1 to 3 years: the present paper discusses 5 of 7 investigated cases (2 with SLE, 2 with dermatomyositis of changing activity, and 1 with an erroneous diagnosis of SLE) in detail.

摘要

在一项早期针对自身免疫性疾病患者的研究中,发现血清蛋白转钴胺素II浓度升高与临床疾病活动度之间的相关性比目前常用的几种检测方法(补体因子C3、抗核抗体滴度和抗天然DNA结合能力)更为可靠。这些发现随后在1至3年的长期观察中得到证实:本文详细讨论了7例被调查病例中的5例(2例系统性红斑狼疮、2例活动度变化的皮肌炎和1例系统性红斑狼疮误诊病例)。

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