活动性自身免疫性疾病中不饱和转钴胺素II增加。
Increased unsaturated transcobalamin II in active autoimmune disease.
作者信息
Fràter-Schröder M, Hitzig W H, Grob P J, Kenny A B
出版信息
Lancet. 1978 Jul 29;2(8083):238-9. doi: 10.1016/s0140-6736(78)91747-6.
Measurements of transcobalamin II (T.C. II) concentrations in 26 patients with lupus erythematosus, 4 with dermatomyositis, 2 with autoimmune haemolytic anaemia, and in 40 immunosuppressed renal-transplant patients showed that T.C. II levels were raised during active phases of autoimmune disease. Changes in T.C. II levels correlated better with the clinical course of autoimmune disease than did changes in C3, the titre of antinuclear antibody, or native D.N.A.-binding capacity.
对26例红斑狼疮患者、4例皮肌炎患者、2例自身免疫性溶血性贫血患者以及40例免疫抑制的肾移植患者的转钴胺素II（T.C. II）浓度进行测量，结果显示在自身免疫性疾病的活动期T.C. II水平升高。与补体C3、抗核抗体滴度或天然DNA结合能力的变化相比，T.C. II水平的变化与自身免疫性疾病的临床病程相关性更好。
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