Hammar M, Larsson L, Tegler L
Acta Obstet Gynecol Scand. 1981;60(4):345-7. doi: 10.3109/00016348109154121.
Up to 30 per cent of pregnant women suffer from leg cramps. The cause of these cramps is not known, but changes in calcium concentration have been suggested. Therefore 42 pregnant women with leg cramps were studied. No differences in total serum or ionized serum calcium concentrations were found as compared with a control group of pregnant women without leg cramps. Twenty-one patients were treated with 1 g calcium orally twice daily for 2 weeks and in this group good clinical improvement was achieved (p less than 0.001). The treatment increased the total serum calcium concentration from 2.25 mmol/l to 2.30 mmol/l but did not alter the ionized serum calcium concentration. Twenty-one untreated patients had the same frequency of cramps and showed no change in serum calcium concentrations throughout the investigation.
高达30%的孕妇会出现腿部抽筋。这些抽筋的原因尚不清楚，但有人提出与钙浓度变化有关。因此，对42名有腿部抽筋的孕妇进行了研究。与没有腿部抽筋的孕妇对照组相比，未发现总血清钙或离子化血清钙浓度有差异。21名患者每天口服1克钙，分两次服用，持续2周，该组患者临床症状有明显改善（p小于0.001）。治疗使总血清钙浓度从2.25毫摩尔/升升至2.30毫摩尔/升，但未改变离子化血清钙浓度。21名未接受治疗的患者抽筋频率相同，且在整个研究过程中血清钙浓度无变化。
