Dahle L O, Berg G, Hammar M, Hurtig M, Larsson L
Department of Obstetrics and Gynecology, Faculty of Health Sciences, Linköping University Hospital, Sweden.
Am J Obstet Gynecol. 1995 Jul;173(1):175-80. doi: 10.1016/0002-9378(95)90186-8.
Our purpose was to determine whether women with pregnancy-related leg cramps would benefit from oral magnesium supplementation.
Seventy-three women with pregnancy-related leg cramps were interviewed about their symptoms in a prospective, double-blind, randomized trial. Initial serum magnesium levels and diurnal magnesium excretion was determined in 50% of the patients. Oral magnesium or placebo was given for 3 weeks, after which new interviews and laboratory analyses were performed.
Serum magnesium levels in these patients were at or below the lower reference limit, as is also often the case in healthy pregnant patients. Oral magnesium substitution decreased leg cramp distress (p < 0.05 compared with the placebo group, p < 0.001 compared with initial complaints), but did not significantly increase serum magnesium levels, excess magnesium being excreted as measured by an increase in urinary magnesium levels (p < 0.002).
Oral magnesium supplementation seems to be a valuable therapeutic tool in the treatment of pregnancy-related leg cramps.
我们的目的是确定患有与妊娠相关腿部抽筋的女性是否能从口服镁补充剂中获益。
在一项前瞻性、双盲、随机试验中，对73名患有与妊娠相关腿部抽筋的女性进行了症状访谈。50%的患者测定了初始血清镁水平和日间镁排泄量。给予口服镁或安慰剂3周，之后进行新的访谈和实验室分析。
这些患者的血清镁水平处于或低于参考下限，健康孕妇也常常如此。口服镁补充剂减轻了腿部抽筋的痛苦（与安慰剂组相比，p < 0.05；与初始症状相比，p < 0.001），但并未显著提高血清镁水平，通过尿镁水平升高测量发现过量的镁被排出（p < 0.002）。
口服镁补充剂似乎是治疗与妊娠相关腿部抽筋的一种有价值的治疗手段。
