Cobden I, Axon A T, Rowell N R
Br J Dermatol. 1981 Aug;105(2):189-93. doi: 10.1111/j.1365-2133.1981.tb01204.x.
Lundh tests of pancreatic exocrine function were performed on twenty unselected patients with systemic sclerosis. Three patients had very low levels of tryptic activity in their intestinal juice and only nine had results which were unequivocally normal. Eight patients had biochemical steatorrhoea, but in six this was associated with intestinal bacterial overgrowth and a seventh had primary biliary cirrhosis. The remaining patient had no cause for steatorrhoea other than the marked pancreatic insufficiency which had been demonstrated. Although pancreatic damage may contribute to malabsorption in systemic sclerosis, it appears to be less important than other factors such as intestinal bacterial overgrowth.
对20例未经挑选的系统性硬化症患者进行了伦德胰外分泌功能试验。3例患者肠液中的胰蛋白酶活性水平极低，只有9例的结果明确正常。8例患者有生化性脂肪泻，但其中6例与肠道细菌过度生长有关，第7例患有原发性胆汁性肝硬化。其余患者除已证实的明显胰腺功能不全外，无脂肪泻的其他病因。虽然胰腺损伤可能导致系统性硬化症中的吸收不良，但它似乎不如肠道细菌过度生长等其他因素重要。
