Bezwoda W, Derman D, Bothwell T, MacPhil P, Levin J, De Moor N
Cancer. 1981 Oct 1;48(7):1623-8. doi: 10.1002/1097-0142(19811001)48:7<1623::aid-cncr2820480725>3.0.co;2-k.
Serum concentrations of carcinoembryonic antigen (CEA), ferritin, and calcitonin were measured in 107 patients with breast cancer, 80 of whom had overt or occult metastatic disease. CEA and ferritin values were statistically higher in those patients with metastases. In contrast, there was no correlation between calcitonin concentrations and the stage of the disease. All 27 subjects with CEA concentrations greater than 80 microgram/liter and 32 of 40 with values between 41-80 microgram/liter had metastatic disease. Ferritin was a definite but less sensitive discriminator, with metastatic disease present in all nine patients having concentrations greater than 400 microgram/liter. Such metastases were invariably hepatic. When the two measurements were used as a combined discriminant, the diagnostic accuracy increased somewhat. All 32 patients with CEA concentration greater than microgram/liter and/or a ferritin concentration greater than 400 microgram/liter had metastatic disease; the same was true for 32 of the 42 subjects with CEA concentration between 41-80 microgram/liter and/or a ferritin concentration between 200-400 microgram/liter. The measurements had prognostic value, both when assessed alone and together, with a median survival from the time of study significantly shorter in those with the highest values.
对107例乳腺癌患者测定了血清癌胚抗原（CEA）、铁蛋白和降钙素水平，其中80例有明显或隐匿性转移疾病。发生转移的患者CEA和铁蛋白值在统计学上更高。相比之下，降钙素浓度与疾病分期之间无相关性。所有27例CEA浓度大于80微克/升的受试者以及40例中32例CEA值在41 - 80微克/升之间的受试者均有转移疾病。铁蛋白是一种明确但敏感性较低的判别指标，所有9例浓度大于400微克/升的患者均有转移疾病，且这种转移均为肝转移。当将这两项检测作为联合判别指标时，诊断准确性有所提高。所有32例CEA浓度大于微克/升和/或铁蛋白浓度大于400微克/升的患者均有转移疾病；42例CEA浓度在41 - 80微克/升之间和/或铁蛋白浓度在200 - 400微克/升之间的受试者中32例也是如此。这些检测单独或联合评估均具有预后价值，值最高的患者自研究开始的中位生存期明显较短。
