Gropp C, Havemann K, Lehmann F G
Cancer. 1978 Dec;42(6):2802-8. doi: 10.1002/1097-0142(197812)42:6<2802::aid-cncr2820420641>3.0.co;2-x.
Carcinoembryonic antigen (CEA) levels were determined in 114 patients with confirmed lung cancer at the time of diagnosis using the CEA Ire-Sorin radioimmunoassay. Elevated CEA values were found in 47%. Most of the patients with high CEA levels had clinically detectable metastases. Ferritin was detectable by the Laurell-electrophoresis in the serum of 58 out of 81 (72%) of the patients with confirmed lung cancer at the time of diagnosis. Ferritin levels were significantly higher in patients with metastases. Serial measurements of CEA and ferritin during radio- and chemotherapy showed that the assay may be useful to evaluate the effects of therapy. Because of some false negative results both CEA and ferritin determinations should be used only in context with other clinical and laboratory findings.
采用癌胚抗原（CEA）Ire-Sorin放射免疫分析法，在114例确诊肺癌患者诊断时测定其癌胚抗原水平。47%的患者癌胚抗原值升高。大多数癌胚抗原水平高的患者有临床可检测到的转移灶。在81例确诊肺癌患者诊断时，通过劳雷尔电泳法在其中58例（72%）患者的血清中检测到铁蛋白。有转移灶的患者铁蛋白水平显著更高。在放疗和化疗期间对癌胚抗原和铁蛋白进行连续测量显示，该检测方法可能有助于评估治疗效果。由于存在一些假阴性结果，癌胚抗原和铁蛋白测定仅应结合其他临床和实验室检查结果使用。
