Baylis P H, De Beer F C
Eur J Clin Pharmacol. 1981;20(5):343-6. doi: 10.1007/BF00615403.
To investigate the effect of potent loop diuretic drugs on the factors that control water excretion, immunoreactive plasma arginine vasopressin was measured at regular intervals for 6 h after intravenous administration of frusemide (40 mg) and piretanide (12 mg) in healthy adults. Despite a large diuresis there was no significant rise in plasma vasopressin compared to controls. Diuretic drug treatment caused small increases in plasma osmolality comparable to the control group, but no change in mean arterial blood pressure. The fall in blood volume of 7% within 1 h of frusemide administration was insufficient to stimulate vasopressin secretion. We conclude that loop diuretic drugs in the dose given have little effect on plasma vasopressin and osmolality but cause a small fall in blood volume in healthy adults.
为研究强效袢利尿剂对控制水排泄的因素的影响，在健康成年人静脉注射速尿（40毫克）和吡咯他尼（12毫克）后，每隔一定时间测量6小时的免疫反应性血浆精氨酸加压素。尽管出现大量利尿，但与对照组相比，血浆加压素没有显著升高。利尿剂治疗使血浆渗透压略有升高，与对照组相当，但平均动脉血压没有变化。速尿给药后1小时内血容量下降7%，不足以刺激加压素分泌。我们得出结论，所给剂量的袢利尿剂对血浆加压素和渗透压影响很小，但会使健康成年人的血容量略有下降。
