Goursot R, Portha B, Levacher C, Picon L
Diabetologia. 1981 Oct;21(4):418-21. doi: 10.1007/BF00252692.
The effect of chronic hypoinsulinism on the development of retroperitoneal adipose tissue was studied in rats injected with streptozotocin at birth. The streptozotocin injection induced an acute neonatal diabetes which regressed spontaneously after one week and led to a chronic state of chemical diabetes in the young and in the adult rat. Growth of chemically diabetic rats was normal although the retroperitoneal adipose tissue showed a relative hypoplasia which appeared at two months and evolved with age so that at 10 months the number of adipose cells in the retroperitoneal adipose tissue was largely decreased with respect to control animals (1.34 +/- 0.12 x 10(6) versus 2.23 +/- 0.11 x 10(6)). This relative hypoplasia was still present at 20 months. Whereas the hypoplasia associated with the chemical diabetes was highly reproducible, the mean adipocyte size was modified in a variable manner but was never significantly decreased in chemically diabetic rats. These findings indicate that insulin is involved in the control of retroperitoneal adipose tissue cellularity and suggest that the effect of hypoinsulinism on adipocyte number does not depend on a decrease of the mean adipocyte volume.
研究了出生时注射链脲佐菌素的大鼠慢性低胰岛素血症对腹膜后脂肪组织发育的影响。链脲佐菌素注射诱发了急性新生儿糖尿病，该糖尿病在一周后自发消退，并导致幼年和成年大鼠出现慢性化学性糖尿病状态。化学性糖尿病大鼠的生长正常，尽管腹膜后脂肪组织显示出相对发育不全，这种发育不全在两个月时出现，并随年龄增长而发展，以至于在10个月时，腹膜后脂肪组织中的脂肪细胞数量相对于对照动物大幅减少（1.34±0.12×10⁶对2.23±0.11×10⁶）。这种相对发育不全在20个月时仍然存在。虽然与化学性糖尿病相关的发育不全具有高度可重复性，但化学性糖尿病大鼠的平均脂肪细胞大小以可变方式改变，但从未显著减小。这些发现表明胰岛素参与了腹膜后脂肪组织细胞数量的控制，并提示低胰岛素血症对脂肪细胞数量的影响不依赖于平均脂肪细胞体积的减小。
