对麻醉大鼠注射儿茶酚胺后诱发的电惊厥活动进行的药理学研究。
A pharmacological investigation of the electrically evoked convulsive activity induced by administration of catechol in the anaesthetized rat.
作者信息
Angel A, Dewhurst D G
出版信息
Br J Pharmacol. 1978 Dec;64(4):539-44. doi: 10.1111/j.1476-5381.1978.tb17315.x.
Abstract
1 The response evoked by electrical stimulation at the wrist has been recorded from muscles of the forelimb of anaesthetized rats induced to convulse by administration of catechol.2 This response can be divided into three temporally distinct components, the characteristics of which have been described.3 The probability of occurrence of the two early components of the response has been measured before and after administration of various drugs. The results show that the first component is not affected by cholinoceptor or adrenoceptor blocking drugs or anticholinesterase agents. The probability of occurrence of the second component is significantly reduced by cholinoceptor blocking drugs and increased by physostigmine.4 The implications of these results in explaining the convulsant actions of catechol are discussed.
摘要
对用儿茶酚诱发惊厥的麻醉大鼠前肢肌肉记录了腕部电刺激所引发的反应。
该反应可分为三个在时间上不同的成分，其特征已作描述。
在给予各种药物之前和之后测量了反应的两个早期成分出现的概率。结果表明，第一个成分不受胆碱受体或肾上腺素受体阻断药物或抗胆碱酯酶剂的影响。胆碱受体阻断药物可显著降低第二个成分出现的概率，而毒扁豆碱则可增加其出现的概率。
讨论了这些结果在解释儿茶酚惊厥作用方面的意义。
相似文献
1
A pharmacological investigation of the electrically evoked convulsive activity induced by administration of catechol in the anaesthetized rat.对麻醉大鼠注射儿茶酚胺后诱发的电惊厥活动进行的药理学研究。
Br J Pharmacol. 1978 Dec;64(4):539-44. doi: 10.1111/j.1476-5381.1978.tb17315.x.
2
Some characteristics of the long-latency component of the evoked muscle response induced by administration of catechol to the anaesthetized rat: a neurophysiological and neuropharmacological investigation.对麻醉大鼠注射儿茶酚胺所诱发的肌肉反应的长潜伏期成分的一些特征：一项神经生理学和神经药理学研究。
Br J Pharmacol. 1984 Sep;83(1):83-8. doi: 10.1111/j.1476-5381.1984.tb10122.x.
3
Sensorimotor cortical representation in the rat and the role of the cortex in the production of sensory myoclonic jerks.大鼠的感觉运动皮层表征以及皮层在感觉性肌阵挛性抽搐产生中的作用。
J Physiol. 1975 Jun;248(2):465-88. doi: 10.1113/jphysiol.1975.sp010984.
4
A pharmacological study of the spontaneous convulsive activity induced by 1,2-dihydroxybenzene (catechol) in the anaesthetized mouse.对麻醉小鼠中由1,2 - 二羟基苯（儿茶酚）诱导的自发惊厥活动的药理学研究。
Br J Pharmacol. 1977 Nov;61(3):433-9. doi: 10.1111/j.1476-5381.1977.tb08437.x.
5
Proceedings: The effects of dorsal column section on the evoked convulsions induced by catechol administration.
J Physiol. 1976 Jul;259(1):17P-18P.
6
Proceedings: Effects of cholinergic drugs on catechol evoked convulsions.
J Physiol. 1976 Jan;254(1):36P-37P.
7
Asynchronous, bilateral, and biphasic temporally unstructured electrical stimulation of amygdalae enhances the suppression of pentylenetetrazole-induced seizures in rats.杏仁核的异步、双侧和双相非时相结构电刺激增强戊四氮诱导的大鼠癫痫发作的抑制。
Epilepsy Res. 2018 Oct;146:1-8. doi: 10.1016/j.eplepsyres.2018.07.009. Epub 2018 Jul 20.
8
Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability.一种用于评估癫痫发作易感性的半自动体外海马脑片试验的药理学验证
J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):223-33. doi: 10.1016/j.vascn.2007.04.008. Epub 2007 May 24.
9
Proceedings: Effect of catechol on the discharge of hind-limb muscle spindles in the anaesthetized rat.
J Physiol. 1976 Jul;259(1):12P-14P.
10
Unilateral subcutaneous bee venom but not formalin injection causes contralateral hypersensitized wind-up and after-discharge of the spinal withdrawal reflex in anesthetized spinal rats.在麻醉的脊髓大鼠中，单侧皮下注射蜂毒而非福尔马林会导致对侧脊髓退缩反射的超敏化卷绕和后放电。
Exp Neurol. 2005 Sep;195(1):148-60. doi: 10.1016/j.expneurol.2005.04.009.
引用本文的文献
1
The effect of the convulsant agent, catechol, on neurotransmitter uptake and release in rat brain slices.惊厥剂儿茶酚对大鼠脑片神经递质摄取和释放的影响。
Br J Pharmacol. 1981 Nov;74(3):715-21. doi: 10.1111/j.1476-5381.1981.tb10483.x.
2
Some characteristics of the long-latency component of the evoked muscle response induced by administration of catechol to the anaesthetized rat: a neurophysiological and neuropharmacological investigation.对麻醉大鼠注射儿茶酚胺所诱发的肌肉反应的长潜伏期成分的一些特征：一项神经生理学和神经药理学研究。
Br J Pharmacol. 1984 Sep;83(1):83-8. doi: 10.1111/j.1476-5381.1984.tb10122.x.
3
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.γ-氨基丁酸不参与儿茶酚胺诱发的癫痫发作。
Br J Pharmacol. 1986 Jan;87(1):167-73. doi: 10.1111/j.1476-5381.1986.tb10168.x.
4
Sites and mechanisms of action of catechol (1,2-dihydroxybenzene) in the rat olfactory cortex slice.儿茶酚（1,2 - 二羟基苯）在大鼠嗅觉皮质切片中的作用位点及作用机制。
Br J Pharmacol. 1986 Jun;88(2):433-40. doi: 10.1111/j.1476-5381.1986.tb10221.x.
5
5-Hydroxytryptamine and myoclonus induced by 1,2-di-hydroxybenzene (catechol) in the guinea-pig.豚鼠中由1,2 - 二羟基苯（儿茶酚）诱导的5 - 羟色胺与肌阵挛
Br J Pharmacol. 1979 Jul;66(3):358-60. doi: 10.1111/j.1476-5381.1979.tb10837.x.
本文引用的文献
1
CHOLINESTERASE-CONTAINING SYSTEMS OF THE BRAIN OF THE RAT.大鼠大脑中含胆碱酯酶的系统
Nature. 1963 Sep 21;199:1160-4. doi: 10.1038/1991160a0.
2
The ascending cholinergic reticular system: neocortical, olfactory and subcortical projections.上行胆碱能网状系统：新皮质、嗅觉及皮质下投射。
Brain. 1967 Sep;90(3):497-520. doi: 10.1093/brain/90.3.497.
3
The distribution of muscarinic receptor sites in the nervous system of the dog.毒蕈碱受体位点在犬神经系统中的分布。
J Neurochem. 1974 Jan;22(1):159-62. doi: 10.1111/j.1471-4159.1974.tb12192.x.
4
The pharmacology of thalamic and geniculate neurons.
Int Rev Neurobiol. 1971;14:1-48. doi: 10.1016/s0074-7742(08)60182-8.
5
Acetylcholine-sensitivity of thalamic neurones: its relationship to synaptic transmission.丘脑神经元的乙酰胆碱敏感性：及其与突触传递的关系。
Br J Pharmacol Chemother. 1968 Mar;32(3):635-51. doi: 10.1111/j.1476-5381.1968.tb00463.x.
6
An analysis of the myoclonic jerks produced by 1, 2-dihydroxybenzene in the rat.
Electroencephalogr Clin Neurophysiol. 1973 Dec;35(6):589-601. doi: 10.1016/0013-4694(73)90212-5.
7
The convulsive action of 1,2-dihydroxybenzene in the anaesthetized rat.
Electroencephalogr Clin Neurophysiol. 1973 Apr;34(4):369-78. doi: 10.1016/0013-4694(73)90088-6.
8
Sensorimotor cortical representation in the rat and the role of the cortex in the production of sensory myoclonic jerks.大鼠的感觉运动皮层表征以及皮层在感觉性肌阵挛性抽搐产生中的作用。
J Physiol. 1975 Jun;248(2):465-88. doi: 10.1113/jphysiol.1975.sp010984.
9
A pharmacological study of the spontaneous convulsive activity induced by 1,2-dihydroxybenzene (catechol) in the anaesthetized mouse.对麻醉小鼠中由1,2 - 二羟基苯（儿茶酚）诱导的自发惊厥活动的药理学研究。
Br J Pharmacol. 1977 Nov;61(3):433-9. doi: 10.1111/j.1476-5381.1977.tb08437.x.
Zotero 插件