对麻醉大鼠注射儿茶酚胺后诱发的电惊厥活动进行的药理学研究。
A pharmacological investigation of the electrically evoked convulsive activity induced by administration of catechol in the anaesthetized rat.
作者信息
Angel A, Dewhurst D G
出版信息
Br J Pharmacol. 1978 Dec;64(4):539-44. doi: 10.1111/j.1476-5381.1978.tb17315.x.
Abstract
1 The response evoked by electrical stimulation at the wrist has been recorded from muscles of the forelimb of anaesthetized rats induced to convulse by administration of catechol.2 This response can be divided into three temporally distinct components, the characteristics of which have been described.3 The probability of occurrence of the two early components of the response has been measured before and after administration of various drugs. The results show that the first component is not affected by cholinoceptor or adrenoceptor blocking drugs or anticholinesterase agents. The probability of occurrence of the second component is significantly reduced by cholinoceptor blocking drugs and increased by physostigmine.4 The implications of these results in explaining the convulsant actions of catechol are discussed.
摘要
对用儿茶酚诱发惊厥的麻醉大鼠前肢肌肉记录了腕部电刺激所引发的反应。
该反应可分为三个在时间上不同的成分，其特征已作描述。
在给予各种药物之前和之后测量了反应的两个早期成分出现的概率。结果表明，第一个成分不受胆碱受体或肾上腺素受体阻断药物或抗胆碱酯酶剂的影响。胆碱受体阻断药物可显著降低第二个成分出现的概率，而毒扁豆碱则可增加其出现的概率。
讨论了这些结果在解释儿茶酚惊厥作用方面的意义。
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