对麻醉小鼠中由1,2 - 二羟基苯（儿茶酚）诱导的自发惊厥活动的药理学研究。
A pharmacological study of the spontaneous convulsive activity induced by 1,2-dihydroxybenzene (catechol) in the anaesthetized mouse.
作者信息
Angel A, Clarke K A, Dewhurst D G
出版信息
Br J Pharmacol. 1977 Nov;61(3):433-9. doi: 10.1111/j.1476-5381.1977.tb08437.x.
Abstract
- The convulsive activity induced by catechol has been examined in anaesthetized mice either by determining the CD50 for the convulsions in drug-treated and control animals, or by studying the effects of various drugs on the total whole body activity. 2. The results indicate that catecholamines play no part in the mechanism of action of catechol. Drugs which alter cerebral catecholamine levels had no effect on the convulsions, nor did the alpha- and beta-adrenoceptor blocking drugs. 3. 5-Hydroxytryptamine (5-HT) could possibly be important, though results with drugs which either change brain 5-HT levels, or block 5-HT receptors were inconsistent. 4. gamma-Aminobutyric acid also appears not to be involved in the mechanism of action of catechol. 5. The results strongly suggest that catechol primarily activates a central cholinergic system, in that muscarinic and nicotinic receptor blocking drugs inhibit, and anticholinesterases potentiate the convulsions.
摘要
- 通过测定药物处理动物和对照动物惊厥的半数惊厥剂量（CD50），或通过研究各种药物对全身总活动的影响，已在麻醉小鼠中研究了儿茶酚诱导的惊厥活动。2. 结果表明，儿茶酚胺在儿茶酚的作用机制中不起作用。改变脑儿茶酚胺水平的药物对惊厥无影响，α和β肾上腺素能受体阻断药物也无影响。3. 5-羟色胺（5-HT）可能很重要，尽管改变脑5-HT水平或阻断5-HT受体的药物的结果并不一致。4. γ-氨基丁酸似乎也不参与儿茶酚的作用机制。5. 结果强烈表明，儿茶酚主要激活中枢胆碱能系统，因为毒蕈碱和烟碱受体阻断药物可抑制惊厥，而抗胆碱酯酶药物可增强惊厥。
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