Pyke D A, Leslie R D
Br Med J. 1978 Dec 2;2(6151):1521-2. doi: 10.1136/bmj.2.6151.1521.
The single-challenge test for chlorpropamide-alcohol flushing (CPAF) was used to study two groups of patients with non-insulin-dependent diabetes and a family history of the disease who were distinguished only by their age at diagnosis (under and over 30). Their relatives were also studied. The proportions of patients showing CPAF in both groups were similar, and the family histories suggested dominant inheritance. When offspring of diabetics in whom the disease was diagnosed early were studied CPAF seemed to precede the appearance of diabetes. We conclude that the patients in both groups had the same, distinct syndrome, which is characterised by diabetes diagnosed at any age that is inherited as an autosomal dominant trait and associated with CPAF. This syndrome, which constitutes about one-fifth of all cases of non-insulin-dependent diabetes, may be detected with a single-challenge CPAF test before the onset of glucose intolerance. CPAF therefore acts as a genetic marker for the syndrome.
采用氯磺丙脲-乙醇潮红（CPAF）单激发试验对两组非胰岛素依赖型糖尿病患者及有该疾病家族史的人群进行研究，这两组仅根据诊断时的年龄（30岁及以下和30岁以上）进行区分。他们的亲属也在研究范围内。两组中出现CPAF的患者比例相似，家族史提示为显性遗传。当对疾病早期诊断的糖尿病患者的后代进行研究时，CPAF似乎先于糖尿病出现。我们得出结论，两组患者具有相同的独特综合征，其特征为任何年龄诊断的糖尿病，以常染色体显性性状遗传并与CPAF相关。这种综合征约占所有非胰岛素依赖型糖尿病病例的五分之一，可在糖耐量异常发作前通过单激发CPAF试验检测出来。因此，CPAF可作为该综合征的遗传标记。
